Choose any/all that apply to the proton-motive force and ATP synthesis. The active pumping of protons through ATP synthase against their concentration gradient provides the energy needed for ATP synthesis. The ATP molecules produced from the pair of electrons provided by NADH have greater potential energy than the ATP molecules produced from the pair of electrons provided by FADH2. Each Beta subunit of ATP synthase has a distinct amino acid sequence that accounts for the three different active sites present in the enzyme. Rotation of the Y subunit creates conformational changes in the active sites of ATP synthase that drive the release of ATP from the enzyme. Inhibition of either ATP synthase or ATP translocase will stop flux through the electron-transport chain.

Choose any/all that apply to the proton-motive force and ATP synthesis. The active pumping of protons through ATP synthase against their concentration gradient provides the energy needed for ATP synthesis. The ATP molecules produced from the pair of electrons provided by NADH have greater potential energy than the ATP molecules produced from the pair of electrons provided by FADH2. Each Beta subunit of ATP synthase has a distinct amino acid sequence that accounts for the three different active sites present in the enzyme. Rotation of the Y subunit creates conformational changes in the active sites of ATP synthase that drive the release of ATP from the enzyme. Inhibition of either ATP synthase or ATP translocase will stop flux through the electron-transport chain.

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter2: Cell Physiology

Section: Chapter Questions

Problem 3SQE

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The proton-motive force drives the rotation of the Y subunit of ATP synthase. This creates conformational changes in the active sites of ATP synthase that accelerate the rate of bond formation between ADP and P, through the stabilization of a tetrahedral intermediate. True False
Which of the following statements concerning oxidative phosphorylation is false? Group of answer choices: The electron transport chain generates an electrochemical gradient that drives the production of ATP. ATP synthase with fewer subunits in its c ring will produce more ATP per proton. A “loose” β subunit of ATP synthase becomes a “tight” site as it produces ATP. When the supply of NADH and QH2 (ubiquinol) decreases, ATP synthase produces more ATP.
Which of the following statements is false concerning the ‘tight binding site’ of ATP Synthase within the natural environment of the mitochondria? Group of answer choices ATP is released from the tight binding site This is a binding site found within an αβ subunits of the F1 portion of ATP Synthase The tight binding forces the reaction of ADP + Pi → ATP The tight binding site has the lowest KM for ATP
Which of the following statements best explains why the activity of ATP-citrate lyase and malic enzyme are often paired together? The use of ATP by ATP-citrate lyase means that NADH needs to be regenerated cytosolically so that more ATP can be generated via shuttle systems and replace the ATP used by ATP-citrate lyase ATP-citrate lyase produces ATP and malic enzyme produces NADPH, both needed in the fatty acid biosynthetic pathway The activity of ATP-citrate lyase and malic enzyme never are correlated, they always function in different realms of metabolism The generation of acetyl CoA is a substrate for fatty acid synthesis in the cytosol and NADPH is generated as the anabolic electron carrier
Kinases catalyze the transfer of a phosphate group from a phosphate donor such as adenosine triphosphate (ATP) to a substrate. A well‑known kinase is hexokinase. Hexokinase catalyzes the first step of the glycolysis cycle, and converts glucose to glucose‑6‑phosphate. The reaction of glucose with ATP is shown. The enzyme‑bound base is abbreviated as :B−, and ATP is abbreviated as a diphosphate bonded to adenosine monophosphate (AMP).
What drives the rotation of the F1 head of ATP synthase? only one answer options: proton movement from intermembrane space to the matrix proton movement from the matrix to the intermembrane space ATP hydrolysis ATP condensation proton movement from the cytoplasm to the intermembrane space
Which of the following statements concerning ATP synthesis is NOT true? a. The open conformation of the ATP synthase is for releasing ATP. b. The gamma subunit in the stalk responds to the flow of H+ and rotates the assembly counterclockwise and thus change the conformations of the active site to synthesize ATP. c. The tight conformation of the ATP synthase is for converting ADP and phosphate to ATP. d. The loose conformation of the ATP synthase is for binding ADP and phosphate. e. Ten protons are required to catalyze the rotation of the subunits so that one ATP is synthesized. Clear my choice
How does the proton motive force lead to production of ATP? A) ATPase requires one proton to make one ATP. B) Protons must be pumped against a concentration gradient from outside of the cell into the cell to rotate the F0 subunit of ATPase for the F1 subunit to make ATP. C) Oxidative phosphorylation of ADP by ATP synthase requires protons as cofactors in the reaction. D) Translocation of three to four protons drives the F0 component of ATPase, which in turn phosphorylates one ADP into ATP.
All of the following are involved in oxidative phosphorylation except: proton motive force NADH Cytochromes Acetyl co-enzyme A ATP synthase
Enzymatic reactions within a cell are often specific for their substrates. Enzymes that use ATP will not efficiently use dATP. Enzymes that use NADH cannot use NADPH instead and enzymes that work on alpha glucose can’t work on beta glucose linkages. What physical property of enzymes causes them to be so picky?
Please explain why hydrolysis of ATP can release much energy by describing how the products of ATP hydrolysis are more stable. Please describe how ATP hydrolysis is used for glucose absorption (i.e. picking up glucose from the small intestine into epithelial cells)
CHOOSE THE CORRECT LETTER 1.In oxidative phosphorylation, which condition drives ATPase to produce ATP?A. low ATP concentration in the mitochondrial matrixB. increase in proton concentration at mitochondrial matrix thus a proton gradientC. increase in proton concentration at the intermembrane space of the mitochondria thus a proton gradientD. low ATP concentration in the intermembrane space of the mitochondria 2.Which of the following molecules are NOT needed to produce energy in oxidative phosphorylation?A.O2B. H2OC.FADH2D.NADH