Describe the steps of endochondral ossification

Human Biology (MindTap Course List)
11th Edition
ISBN:9781305112100
Author:Cecie Starr, Beverly McMillan
Publisher:Cecie Starr, Beverly McMillan
Chapter5: The Skeletal System
Section: Chapter Questions
Problem 3RQ: Describe how bone first develops.
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Describe the steps of endochondral ossification

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Endochondral ossification is one of the two fetal development of  bone tissue in the mammalian skeletal system. During endochondral ossification cartilage is present and this cartilage is replaced by bone to from growing skeleton system. This process mainly occurs in three sites; The physis, epiphysis and the cuboidal bones of the carpus and tarsus.

In the physis, chondrocytes is present, and it can be divided into three layers according to growth and development of bones. The layer closest to metaphysis proliferative zone in which cells actively divides and after that hypertrophic level is present in which cells from proliferative zone is migrated. Farther from metaphysis is the resting zone, as the name itself suggest a zone where cells are in resting phase.

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