Discuss the development of rheumatic fever and rheumatic
heart disease.
Rheumatic fever is a systemic disease. It is caused by group A beta-hemolytic streptococcal infection. This is the disease of childhood and recurrent type. Rheumatoid fever is characterized by diffuse inflammation of connective tissue involving subcutaneous tissue, heart, blood vessels, central nervous system, and joints.
The beta-hemolytic streptococcal infection causes streptococcal throat infection. If left untreated it leads to the development of rheumatic fever. As the result of infection of the beta-hemolytic streptococcal body produces antibodies against them. Due to similarity in human connective tissue and streptococcal component antibodies causes a cross-reaction within human tissue that leads to immunological inflammation and damage to human tissue like the heart, central nervous system, joint and connective tissue. All layer of the heart and mitral wall gets inflamed. Valve regurgitation and stenosis that leads to heart failure.
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