DNA has pKa ≈ 1.0. At normal pH what would the charge be for a double helix that is chain 50 angstroms long?
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DNA has pKa ≈ 1.0. At normal pH what would the charge be for a double helix that is chain 50 angstroms long?
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- A typical bacterial DNA has a molar mass of 4 × 109 g m ol-1 . Approximately how many nucleotides does itcontain?The pKa of the side chain imidazole group of histidine is 6.0. what is the ratio of uncharged to charged side chains at pH 7.0?A protein has a molecular weight of 24kDa. You want a 0.5µM solution of the protein in 75mL. How much of the protein do you add (in micrograms)?
- Each group will be provided with 20 g double-stranded DNA oligomer in STE buffer (0.1M NaCl/ Tris/ 10 mM EDTA, pH 7.4). The sequence of one strand of the oligomer is: 5’-AATGGTACGTATACTTTAT-3’ - show a table of % denaturation of DNA at different temperatures, using the equation provided in “Calculation” - plot a graph of % denaturation of DNA vs different temperatures with clear label and title, and hence determine the experimental Tm of the DNA sample - calculate the theoretical Tm of the sample using Marmur and Doty equation, compare the experimental Tm with theoretical Tm of the DNA sampleThe pKa of the side chain of Histidine is 6.0. What is the ratio of uncharged to charged side chains at pH 7.0?Nucleic acids are polymers of just four different monomers in a linear arrangement. How many different sequences are available if one makes a polymer with only 40 monomers? How does this number compare with Avogadro’s number?
- The pKa of the side-chain imidazole group of histidine is 6.0. What is the ratio of uncharged to charged side chains at a pH of 7.4?In the image attached, there are 4 nitrogenous bases plus ribose used to generate strands of DNA. They are oriented with hydrogen bonding regions aligned. A. Diagram the chemical structure of cytosine hydrogen-bonded to guanine in normal DNA. Please show the H bond interactions clearly with a dotted line. B. In a second diagram, show the enol form of cytosine following a tautomeric shift. Include in the diagram how this change shifts hydrogen bonding characteristics and a new binding partner for this nucleotide.Novel antiviral agents isolated from Caribbean sponges led to the development of vidarabine, the first nucleoside drug used to treat herpes infections. (a) What monosaccharide and base are present in vidarabine? (b) Draw the structure of cytarabine, an anticancer nucleoside composed of cytosine and the same monosaccharide unit.
- Why DNA contains of NaOH (pH=13.5) gave the lowest melting temperature ?the amino acid histidine has three ionizable groups with pKa values of 1.8, 6.0, and 9.2. In a solution at PH 5.4 what percentage of the histidine side chains will carry a postive charge?If the G+C content of a sample of DNA is 46%, what are the proportions of all four nucleotides?