Explain the processes of upregulation and downregulation and how these processes lead to tolerance and withdrawal, using opioids as an example. Because of repeated administration of opioids, what changes happen in the nervous system, and what are BOTH the acute effects of opioid use and withdrawal symptoms from opioids.

Curren'S Math For Meds: Dosages & Sol
11th Edition
ISBN:9781305143531
Author:CURREN
Publisher:CURREN
Chapter10: Reconstitution Of Powdered Drugs
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Explain the processes of upregulation and downregulation and how these processes lead to tolerance and withdrawal, using opioids as an example. Because of repeated administration of opioids, what changes happen in the nervous system, and what are BOTH the acute effects of opioid use and withdrawal symptoms from opioids.

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