Explain the SPECIFIC mechanism(s) by which moderate to advanced emphysema leads to right-sided heart failure - i.e. discussion the pathogenesis of emphysema which may alter ventilation/perfusion balance.  Additionally, do you think Albuterol, a commonly prescribed inhaled beta-agonist, would be of benefit in these patients?  Why or why not.   Lastly, explain what chemical is primarily responsible for stimulus to breathe and how this is altered in these patients.  Why might excessive oxygenation of these patients lead to excessive somnolence and even death?

Human Physiology: From Cells to Systems (MindTap Course List)
9th Edition
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Lauralee Sherwood
Chapter13: The Respiratory System
Section13.5: Control Of Respiration
Problem 1CYU
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Explain the SPECIFIC mechanism(s) by which moderate to advanced emphysema leads to right-sided heart failure - i.e. discussion the pathogenesis of emphysema which may alter ventilation/perfusion balance.  Additionally, do you think Albuterol, a commonly prescribed inhaled beta-agonist, would be of benefit in these patients?  Why or why not.  

Lastly, explain what chemical is primarily responsible for stimulus to breathe and how this is altered in these patients.  Why might excessive oxygenation of these patients lead to excessive somnolence and even death?

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