explain this result to me in a brief way that I can understand: here is the link where I got the image from: https://mdpi-res.com/d_attachment/ijms/ijms-21-05129/article_deploy/ijms-21-05129.pdf?version=1595262192
explain this result to me in a brief way that I can understand: here is the link where I got the image from: https://mdpi-res.com/d_attachment/ijms/ijms-21-05129/article_deploy/ijms-21-05129.pdf?version=1595262192
Chapter8: Forms Of Drugs And How They Act
Section: Chapter Questions
Problem 28RQ
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Question
Please could you explain this result to me in a brief way that I can understand: here is the link where I got the image from: https://mdpi-res.com/d_attachment/ijms/ijms-21-05129/article_deploy/ijms-21-05129.pdf?version=1595262192
Transcribed Image Text:4:58 p. m. Lun 2 oct.
2.5. Blood Analyses
Patients blood samples analyzed before treatment did not show any significant deviations from
the normal range of chemistry and hematology parameters (Figure 4 and Table 2). This confirmed our
assumption that all four dogs were healthy except for the motoric disruption associated with spinal
injury. Blood chemistry results after treatment confirmed that our cell-free therapy was safe and did
not have negative effects on liver and kidney, or other vital organ function. Similarly, the results from
hematology did not reveal any significant changes from the normal range of parameters, except in two
cases. Dog M (German Shepherd) had a slightly elevated mean platelet volume (MPV) level before
treatment, while after treatment the MPV dropped to the normal physiological range. The second Dog
T (Bichon) showed decreased mean cell volume (MCV) after treatment. However, while we have to
Int. J. Mol. Sci. 2020, 21, 5129
Glucose
state that the changes in each given parameter were slightly shifted from the normal range in both
dogs, this was without any harmful clinical impact on the patients.
Dog B Dog M Dog T
Nomal range 4,11-7,95
before Tafter T
Albumine
De Z
L
Dog B D M D T Dog 2
Nommal ange 23-40
before T after T
10
Hematological Parameters
RBC (x10¹2/L)
HCT (%)
Dog B
Creatinine
Dog B Dog M Dog T Dog Z
Normalange 44-159mL/L
Dog B
before T wafer T
Globuline
Dog M
Day T
Nomal range 31 L
before T after T
mdpi-res.com
Ratio BUN/CREA
Dog T
Dog M
before The T
Dog Z
Dog B
BT
AT
5.97 8.09
39.1 51.3
Dog Z
Dog M
Dog B Dog M Dog T Dog Z
Nomal ang 2,5-9,6 mmol/L
100
BT
7.53
48.4
Urea
before I wafter T
T
Alanine Aminotransferase
(ALT)
Dog B
Dog B Dog M Dog T Dog Z
Nomal range 10-125 UL
before T
Ratio ALB/GLOB
Dog M Dog T
before T water T
Dog Z
E
Dog T
AT BT AT
7.97 8.75 6.27
51.3 55.6 38.1
Figure 4. Biochemistry parameters before treatment (before T) and after treatment (after T), blood urea
nitrogen (BUN), creatinine (CREA), ALB (albumin), GLOB (globulin).
Total Protein
Table 2. Hematology parameters before treatment (BT) and after treatment (AT), RBC (red blood cells),
HCT (hematocrit), HGB (hemoglobin), MCV (mean corpuscular volume), MCH (mean corpuscular
hemoglobin), MCHC (mean corpuscular hemoglobin concentration), RDW (red cell distribution width),
RETIC (reticulocytes), WBC (white blood cells), NEU (neutrophils), LYM (lymphocytes), MONO
(monocytes), EOS (eosinophils), BASO (basophiles), PLT (platelets), MPV (mean platelet volume), PDW
(platelet distribution width), PCT (plateletcrit).
7 of 21
Dog B Dog M Dog T Dog 2
Normal range 32-82 gL
before I after T
Alkaline Phosphatase
(ALP)
Dog B Dog M Dog T Dog Z
Nomal range 23-212 UL
TT
Dog Z
BT AT
6.24 7.35
39.3 50.7
Normal Ranges
5.65-8.87
37.3-61.7
@99%
Transcribed Image Text:Table 2. Hematology parameters before treatment (BT) and after treatment (AT), RBC (red blood cells),
HCT (hematocrit), HGB (hemoglobin), MCV (mean corpuscular volume), MCH (mean corpuscular
hemoglobin), MCHC (mean corpuscular hemoglobin concentration), RDW (red cell distribution width),
RETIC (reticulocytes), WBC (white blood cells), NEU (neutrophils), LYM (lymphocytes), MONO
(monocytes), EOS (eosinophils), BASO (basophiles), PLT (platelets), MPV (mean platelet volume), PDW
(platelet distribution width), PCT (plateletcrit).
Hematological Parameters
RBC (x10¹2/L)
HCT (%)
HGB (g/DL)
MCV (fl)
MCH (pg)
MCHC (g/DL)
RDW (%)
%RETIC
RETIC (K/μL)
RETIC-HGB (pg)
WBC (x109/L)
% NEU
%LYM
%MONO
%EOS
%BASO
Int. J. Mol. Sci. 2020, 21, 5129
Hematological Parameters
NEU (x10⁹/L)
LYM (x109/L)
MONO (x10⁹/L)
EOS (x10⁹/L)
BASO (x109/L)
PLT (K/μL)
MPV (fl)
PDW (FL)
PCT (%)
D
Dog B
BT AT
5.97 8.09
39.1 51.3
14.1
17.6
65.5 63.4
23.6
21.8
36.1
34.3
14.7
18.9
0.8
0.7
44.8 57.4
25.9
27.6
9.91 11.1
67.7 74.7
20.6 16.6
6.6 4.4
5.1
3.9
0
0.4
Dog B
BT AT
6.71 8.3
2.04 1.84
0.65 0.49
0.1 0.43
0
0.04
376
254
12
11.9
0.45 0.9
11.6
10
Dog M
BT
7.53
48.4
16.2
64.3
21.5
33.5
18.3
0.7
48.9
24.4
9.7
71.1
21.2
6.8
0.8
0.1
Table 2. Cont.
Dog M
Dog T
AT
BT AT
7.97
8.75 6.27 6.24
7.35
51.3
55.6 38.1 39.3
50.7
17.3
19 134 13.2
16.6
64.4
63.5
60.8 63 69
21.4 21.2 22.6
33.7 34.2 35.2 33.6 32.7
21.7 21.7
18.1 18.9 15.9 14.4
14.9
0.9 0.1 0.2 0.3 0.5
73.3 12.3 15 20.6 33.8
22.4 25.6 23.6 241 25.5
9.18 7.52 15.46 11.93 6.22
71 72 72.2 75.5 65
23.3 21.9 19.1 11.7 26.8
3.5
3.3 5.9 4.4 5.5
2.1 2.7
2.7 8.2
1.1
0.1
0.1
0.1 0.2
1.6
BT
6.89
2.06
0.66
0.08
0.01
164
16.7
not measured
0.27
Dog Z
BT AT
Dog T
BT AT BT
AT
AT
6.52
5.41 11.16 9.01 4.04
1.67
2.14 1.65 2.95 1.39
0.32 0.25 0.91 0.53 0.34
0.19
0.98 0.07
0.01
0.01
0.2 0.42
0.02
245 293
0.02 0.1
348
387 268
10 11.8 11.8 11.2 10.2
10.2 11.3 10.5 9.4 10.7
0.35 0.29 0.35 0.43 0.3
Dog Z
Normal Ranges
5.65-8.87
37.3-61.7
13.1-20.5
61.6-73.5
21.2-25.9
32-37.9
13.6-21.7
10-110
22.3-29.6
5.05-16.76
60-77
12-30
3-10
2-10
0-1
8 of 21
Normal Ranges
2.95-11.64
1.05-5.10
0.16-1.12
0.06-1.23
0.00-0.10
148-484
8.7-13.2
9.1-19.4
0.14-0.46
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