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Social ScienceHow do the antifungal drugs such as Polyenes, Griseofulvin, Azoles, and 5-flurocytosine affect fungal cells?
How do the antifungal drugs such as Polyenes, Griseofulvin, Azoles, and 5-flurocytosine affect fungal cells?
Expert Answer
Chemicals are used as antifungal agents. They affect the vital process of the fungal cell and affect the endospores as well.
Effect of polyenes on fungal cells:
- Affects cell membrane permeability by inhibiting ergosterol
- Causes leakage of cell contents to outside
Effect of griseofulvin on fungal cells:
- Disrupts assembly and function of microtubules in the fungal cell
- Inhibits spindle fiber machinery during cell division.
Effect of azoles on fungal cells:
- Affects cell membrane permeability by inhibiting ergosterol biosynthesis
- Affects cell membrane fluidity
- Affects membrane-bound enzymes
Effect of 5-flurocytosine on fungal cells:
- Inhibits nucleic acid bio...
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Biology
Fungi and Lichen
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