Individuals infected with herpes simplex virus (HSV) mount protective antibody responses directed against surface glycoproteins of the virus. These antibodies are critical to viral clearance. The act to neutralise any virus trying to infect a person’s cells as well as activating the classical pathway of complement and cytotoxic cell-mediated killing of infected target cells. Having a deficiency in the complement component C3 greatly impairs a person’s ability to control HSV infections. To understand this further, you will investigate this in the lab. Using C3-deficient mice, you infect them with HSV at day 0 and then a second time 4 weeks later. A hypothesis is a tentative answer to a scientific question and is an important part of practical experiments. A testable hypothesis is statement that can be proved or disproved as a result of experimentation. You perform an ELISA to measure the antibody response of the C3-deficient and normal mice (referred to as wild-type – WT) infected with HSV. The results are shown in Figure 1. Q. Looking at Figure 1, describe the results of the ELISA.
Individuals infected with herpes simplex virus (HSV) mount protective antibody responses directed against surface glycoproteins of the virus.
These antibodies are critical to viral clearance. The act to neutralise any virus trying to infect a person’s cells as well as activating the classical pathway of complement and cytotoxic cell-mediated killing of infected target cells. Having a deficiency in the complement component C3 greatly impairs a person’s ability to control HSV infections.
To understand this further, you will investigate this in the lab. Using C3-deficient mice, you infect them with HSV at day 0 and then a second time 4 weeks later.
A hypothesis is a tentative answer to a scientific question and is an important part of practical experiments. A testable hypothesis is statement that can be proved or disproved as a result of experimentation.
You perform an ELISA to measure the antibody response of the C3-deficient and normal mice (referred to as wild-type – WT) infected with HSV. The results are shown in Figure 1.
Q. Looking at Figure 1, describe the results of the ELISA.
Trending now
This is a popular solution!
Step by step
Solved in 2 steps
