Kindly mention the indications for clopidogrel in acute coronary syndrome (ACS). Should it be used along with aspirin or alone if the latter is contraindicated? Are there any studies that combine both with either low-molecular-weight heparin (LMWH) or unfractionated heparin? How long should clopidogrel be continued
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Kindly mention the indications for clopidogrel in acute coronary syndrome (ACS). Should it be used along with aspirin or alone if the latter is contraindicated? Are there any studies that combine both with either low-molecular-weight heparin (LMWH) or unfractionated heparin? How long should clopidogrel be continued?
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- Discuss the metabolic changes that take place in aspirin. How can it cause methemoglobenemia?What is the maximum allowable dosage of the most commonly used anesthetic solution i.e. 2% Lidocaine HCl with 1:100,000 epinephrine for a 52 kg healthy adult?What is the maximum allowable dosage of the most commonly used anesthetic solution i.e. 2% Lidocaine HCl with 1:100,000 epinephrine for a healthy adult?
- Treatment with the drug carvedilol for heart failure is initiated with a dose of3.125 mg twice daily and then increased every two weeks with twice-daily doses of6.25 mg, 12.5 mg, and 25 mg. How many of each of these tablet strengths shouldbe dispensed for this protocol?Aspirin is considered as an acidic drug given at a dose of 80 mg tablet as an antithrombotic agent for patients with angina and prevention of myocardial and cerebral infarction. In today’s market, some preparations of aspirin would be given as 100 mg enteric coated tablet. Why is the enteric coated tablet given in 100 mg dose as compared to the compressed tab of 80 mg only?Hydroxyurea has been shown to increase the expression of fetal hemoglobin in adult red blood cells, by a mechanism that remains unclear. Explain why hydroxyurea can be a useful therapy for patients with sickle-cell anemia.
- Mrs B presents you with a prescription for warfarin tablets 1 mg. The directions are to take 6 mg at 6pm that evening, followed by alternating daily doses of 4 mg and then 3 mg (as long as her INR remains within the recommended range). What is the exact number of warfarin 1 mg tablets required for a 28 day supply assuming her INR remains in range?Match the following descriptions to the given choices. Enzyme involved in the conversion of arachidonic acid to leukotrienes Enzyme inhibited by non-steroidal anti-inflammatory drugs (NSAIDS) in prostaglandin synthesis Promote platelet aggregation and smooth muscle contraction Parent structure of prostaglandins A. Cyclooxygenase B. Lipoxygenase C. PGH2 D. TxB2 E. Prostanoic acid F. Arachidonic acidA drug has been developed for oral administration as a rapidly dissolving capsule. This drug is also available as an intravenous formulation. Pharmacokinetic studies with both formulations in a relevant patient population provided the following values for absorption rate constant, clearance, volume of distribution and bioavailability: ka = 1.0 h-1; Cl = 9 L/h; V = 90 L; and F = 0.8. Calculate the drug concentration (in the blood) 8 h after a 1000 mg dose is administered orally.
- In pediatric systolic or pulseless arrest, Epinephrine (1 mg/mL, 1mL amp) is dosed at 0.01mg/kg with a maximum single dose of 1mg every 3-5 minutes until with ROSC. Epinephrine is prepared by mixing 1mg of Epinephrine with 9mL of NSS, and this is the stock solution in which the doses to be administered are aspirated.Patient YH, weighing 26kg, was found unresponsive and pulseless. ACLS was started. What is the appropriate volume (in 2 decimal places) to be aspirated from the Epinephrine admixed solution per dose?Present the rationale for clinical applications of niacin. What are major side effects?Suggest the effects of each of the following mutations on the physiologicalrole of chymotrypsinogen:(a) R15S(b) C1S(c) T147S