Answered: male contraceptive

Biology (MindTap Course List)

11th Edition

ISBN:9781337392938

Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Publisher:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Chapter51: Animal Development

Section: Chapter Questions

Problem 2TYU

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Question

1. Predict the fertilization problems if the Ca⁺² wave gets blocked?
2. One of the goals of modern-day pharmacology is to develop a male contraceptive.
Go through the steps of fertilization and determine what steps do you think it might be possible to block
pharmacologically in order to produce such a contraceptive for males?

Expert Solution

Step 1

The process of fertilization involves a sperm fusing with an ovum. The sperm plasma then fuses with the egg's plasma membrane.
The result of this union, leads to the production of a zygote cell or fertilized egg, initiating prenatal development.

use of calcium in fertilization and in early development

which an activating substance enters the egg from the sperm on sperm-egg fusion, activating the egg by stimulating phospholipase C activation through a src family kinase pathway and in mammals by the diffusion of a sperm-specific phospholipase C from sperm to egg on sperm-egg fusion.
The fertilization calcium wave is then set into the context of cell cycle control and the mechanism of repetitive calcium spiking in mammalian eggs is investigated.
calcium signals control cell division in early embryos and that calcium signals are essential at all three stages of cell division in early embryos.
phosphoinositide signaling pathways control the resumption of meiosis during oocyte maturation is considered

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