Mrs B, aged 43 years, weight 56 kg, requires a loading dose of drug B.  The target plasma concentration is 18.9 mg/ L, volume of distribution is 0.5 L/ kg, the salt factor is 0.9 and bioavailability fraction is 1. What is the intravenous loading dose (LD) of Drug B in milligrams (mg)? units - mg LD = Cp desired x Vd                         S x F   Where Cp desired is the target plasma

Curren'S Math For Meds: Dosages & Sol
11th Edition
ISBN:9781305143531
Author:CURREN
Publisher:CURREN
Chapter13: Dimensional Analysis/units Conversion
Section: Chapter Questions
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Mrs B, aged 43 years, weight 56 kg, requires a loading dose of drug B.  The target plasma concentration is 18.9 mg/ L, volume of distribution is 0.5 L/ kg, the salt factor is 0.9 and bioavailability fraction is 1.

What is the intravenous loading dose (LD) of Drug B in milligrams (mg)?

units - mg

LD = Cp desired x Vd

                        S x F

 

Where Cp desired is the target plasma concentration; Vd is the volume of distribution; S is the salt factor and F is the bioavailability fraction

 

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