The nurse is to administer a medication to a hospitalized client . Which of the following factors should a nurse consider when administering medications to an older adult ? (Select all that apply .)  a. Altered peripheral venous tone An increased number of protein -binding sites  b. An increased difficulty with the penetration of fat -soluble drugs  c. A decline in enzyme production needed for drug metabolism  d. An increased gastric emptying time e.  A decline in liver function

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