This was the HIPPo pathway diagram given to us by our physiology Lecturer. Can you please kindly explain this digram, like what each protein is and and everything about the hippo pathway. Thank you.

Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
Chapter5: Abbreviations And Systems Of Measurement
Section: Chapter Questions
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This was the HIPPo pathway diagram given to us by our physiology Lecturer. Can you please kindly explain this digram, like what each protein is and and everything about the hippo pathway. Thank you.

20-1
b-catenin
ROCK
Rho
20-1
14-3-3
YAP/TAZ
catenin
143-3
O
YAP/TAZ
P13K
EGFR
Rassf
actin
(MST1/2)
YAP/TAZ)
TEAD
Raf
YAP/TAZ
AMPK
Induces proliferation
MST1/2
Wnt
www.
LATS1/2
LATS1/2
YAP/TAZ
TEAD
143-3
?
143-3
Frizzled
degradation
143-3
YAP/TAZ
HIPPO pathway ON
HIPPO pathway OFF
Transcribed Image Text:20-1 b-catenin ROCK Rho 20-1 14-3-3 YAP/TAZ catenin 143-3 O YAP/TAZ P13K EGFR Rassf actin (MST1/2) YAP/TAZ) TEAD Raf YAP/TAZ AMPK Induces proliferation MST1/2 Wnt www. LATS1/2 LATS1/2 YAP/TAZ TEAD 143-3 ? 143-3 Frizzled degradation 143-3 YAP/TAZ HIPPO pathway ON HIPPO pathway OFF
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