What affect does hydrochloric acid have on pespinogen? A.Causes pepsinogen to become lipase B.Causes pepsinogen to become pepsin C.Causes a positive feedback loop to add more HCl D.Causes ulcers

Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
ChapterCRE2: Comprehensive Review Exam For Part 2
Section: Chapter Questions
Problem 25CEP2
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What affect does hydrochloric acid have on pespinogen?

A.Causes pepsinogen to become lipase
B.Causes pepsinogen to become pepsin
C.Causes a positive feedback loop to add more HCl
D.Causes ulcers
Expert Solution
Introduction

The process of digestion involves the breaking of complex food particles into smaller ones so that they can be easily absorbed and assimilated by all the cells of the body to obtain energy. Digestion involves a complex set of chemical reactions by the digestive enzymes in which decomposition plays a significant role.

Explanation

Answer: Option B. “Causes pepsinogen to become pepsin”

Hydrochloric acid contributes to protein digestion by supplying H+ which activates pepsinogen, the precursor of pepsin. The hydrochloric acid creates an acidic environment, which allows pepsinogen to unfold and cleave itself in an autocatalytic fashion, thereby generating pepsin. Proteins are reduced to fragments of various sizes, called as peptides, or amino acids by pepsin so they can eventually be absorbed in the small intestine. Therefore, the option b is correct.

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