What if the SHH you are making needs to be accumulated in the cell so that it can be released all at once into the extracellular space at a specific time? How would you store the produced SHH? What would need to occur to release all of the SHH from storage into the extracellular space?
What if the SHH you are making needs to be accumulated in the cell so that it can be released all at once into the extracellular space at a specific time? How would you store the produced SHH? What would need to occur to release all of the SHH from storage into the extracellular space?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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What if the SHH you are making needs to be accumulated in the cell so that it can be released all at once into the extracellular space at a specific time? How would you store the produced SHH? What would need to occur to release all of the SHH from storage into the extracellular space?
![NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE
Organelles in Concert:
Modeling the Coordination of Cell Structures
by
Alexandra V. Tremblay
Department of Biology
University of North Georgia, Dahlonega, GA
Sonic Hedgehog Protein Synthesis
After completing this activity, you should be able to describe the function(s) and spatial arrangement of each organelle within the
cell and be able to describe the coordination among the organelles necessary for cellular function.
Background:
Sonic Hedgehog protein (SHH) is an essential 462 amino acid protein produced in vertebrates during the early stages of
embryonic development [1]. The protein is encoded by the shh gene, which in humans is located on chromosome 7 [2]. The SHH
protein that is produced by this gene is called a "morphogen," or chemical agent that drives morphological changes in an
organism. After synthesis, a cholesterol molecule is added to the C-terminal end of the amino acid sequence, and SHH is
secreted by the cell into the extracellular space [3]. Once SHH is outside the cell, it forms a concentration gradient that promotes
the development of several types of specialized tissue including the brain, spinal cord, and limbs and digits in vertebrates [4].](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F8bce45ac-d4bb-4c39-ab64-6aff595f666a%2F9038ba58-53cb-4678-884a-063a723b3ef9%2Fxdziyg_processed.png&w=3840&q=75)
Transcribed Image Text:NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE
Organelles in Concert:
Modeling the Coordination of Cell Structures
by
Alexandra V. Tremblay
Department of Biology
University of North Georgia, Dahlonega, GA
Sonic Hedgehog Protein Synthesis
After completing this activity, you should be able to describe the function(s) and spatial arrangement of each organelle within the
cell and be able to describe the coordination among the organelles necessary for cellular function.
Background:
Sonic Hedgehog protein (SHH) is an essential 462 amino acid protein produced in vertebrates during the early stages of
embryonic development [1]. The protein is encoded by the shh gene, which in humans is located on chromosome 7 [2]. The SHH
protein that is produced by this gene is called a "morphogen," or chemical agent that drives morphological changes in an
organism. After synthesis, a cholesterol molecule is added to the C-terminal end of the amino acid sequence, and SHH is
secreted by the cell into the extracellular space [3]. Once SHH is outside the cell, it forms a concentration gradient that promotes
the development of several types of specialized tissue including the brain, spinal cord, and limbs and digits in vertebrates [4].
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