What is a complex of proteins that folds up the telomeres into a structure that shields single-stranded TTAGGG sequences from nucleases and NHEJ enzymes?
Proteins
We generally tend to think of proteins only from a dietary lens, as a component of what we eat. However, they are among the most important and abundant organic macromolecules in the human body, with diverse structures and functions. Every cell contains thousands and thousands of proteins, each with specific functions. Some help in the formation of cellular membrane or walls, some help the cell to move, others act as messages or signals and flow seamlessly from one cell to another, carrying information.
Protein Expression
The method by which living organisms synthesize proteins and further modify and regulate them is called protein expression. Protein expression plays a significant role in several types of research and is highly utilized in molecular biology, biochemistry, and protein research laboratories.
What is a complex of proteins that folds up the telomeres into a structure that shields single-stranded TTAGGG sequences from nucleases and NHEJ enzymes?
A complex of protein is generally found in many eukaryotic cell, whose primary function is the protection of telomere from DNA repair mechanism. It also regulates the activity of telomerase enzyme.
A telomeric DNA in mammals and other vertebrates, consists of recurring double-stranded 5'-TTAGGG-3' (also known as G-strand) sequences along with a complementary sequence in the other strand, 3'-AATCCC-5' (called as C-strand) that ends with a 50-400 nucleotide overhang.
The absence of the protein complex causes uncapping of telomere that can further damage signalling pathways that may reault in homology directed repair (HDR), Non-homologous end joining (NHEJ), genomic unstability, end-to-end fusion, senescence or apoptosis.
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