What would be reason why morphine show less analgesic activity after oral administration.?

Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
Chapter19: Analgesics, Sedatives, And Hypnotics
Section: Chapter Questions
Problem 13CRQ
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#3# What would be reason why morphine show less analgesic activity after oral administration.?

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