Which of these scenarios will result in a severe phenotype of osteogenesis imperfecta and why? 1 2 3 COLLAI locus 179 COLIA2 locus missense mutation major mutation 79 曲 ABNORMAL EXPRESSION NO EXPRESSION EXPRESSION n chains n normal chains +n mutant chains n chains n chains 2n chains n chains normal procollagen molecules S procollagen molecules n procollagen molecules (three chains) Page 1

Human Biology (MindTap Course List)
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Author:Cecie Starr, Beverly McMillan
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Chapter5: The Skeletal System
Section: Chapter Questions
Problem 4SQ: The hollow center of an osteon (Haversian system) provides space for what vital part of compact bone...
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Which of these scenarios will result in a severe phenotype of osteogenesis
imperfecta and why?
1
2
major
mutation
missense
COLIA1
locus
179
COLIA2
locus
79
mutation
EXPRESSION
ABNORMAL
EXPRESSION
NO
EXPRESSION
n chains
n normal chains
+n mutant chains
n chains
n chains
2n chains
n chains
18
normal procollagen
molecules
S procollagen
molecules
n procollagen
molecules
(three chains)
Page 1
Transcribed Image Text:Which of these scenarios will result in a severe phenotype of osteogenesis imperfecta and why? 1 2 major mutation missense COLIA1 locus 179 COLIA2 locus 79 mutation EXPRESSION ABNORMAL EXPRESSION NO EXPRESSION n chains n normal chains +n mutant chains n chains n chains 2n chains n chains 18 normal procollagen molecules S procollagen molecules n procollagen molecules (three chains) Page 1
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