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Why can’t an individual with Parkinson’s disease be given dopamine to relieve his symptoms?

Essentials of Pharmacology for Health Professions

7th Edition

ISBN:9781305441620

Author:WOODROW

Publisher:WOODROW

Chapter20: Psychotropic Medications, Alcohol, And Drug Abuse

Section: Chapter Questions

Problem 13CRQ

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How is dopamine activity related to schizophrenia,drug addiction, and Parkinson’s disease?
Haloperidol is a drug that interferes with the transmission of dopamine among neurons. What effect would it probably have on someone who is suffering from Parkinson's disease?
What is the function of Dopamine (DA)?
If incoming serotonin axons were destroyed, LSD would still have its full effects. However, if incoming dopamine axons were destroyed, amphetamine and cocaine would lose their effects. Explain the difference.
Describe how the process of opioid withdrawal leads to a reduction in the release of dopamine? Explain in a few sentences
Why do opiate drugs provide pain relief?
What is the impact and mode of action of cocaine on dopamine levels in the brain?
Why are the effects of antipsychotic drugs equally compatible with the dopamine hypothesis and the glutamate hypothesis?
Monoamine oxidase inhibitors are sometimes used in the treatment of Parkinson’s disease. What is their mechanism of action? a. They inhibit the breakdown of dopamine. b. They inhibit the reuptake of dopamine by glia. c. They inhibit the reuptake of dopamine by neurons. d. They inhibit the synthesis of norepinephrine from dopamine. e. They inhibit the synthesis of dopamine.
Ordinarily, patients with advanced Parkinson’s disease (who have damage to dopamine-releasing axons) move very slowly if at all. However, during an emergency (e.g., a fire in the building), they may move rapidly and vigorously. Suggest a possible explanation.
In schizophrenia, the neurons affected by dopamine are overstimulated. This condition is treated with drugs like chlorpromazine (Thorazine), which bind to the affected receptors and inhibit the dopamine signal. Does chlorpromazineact as an agonist or antagonist?
What effects do the opioid analgesics have on the CNS.