You are presented with the following clinical scenario: "A 50 year old patient presents with fatigue, night sweats and weight loss. Flow cytometry shows increased numbers of immature leukocytes." Using your knowledge of immunology and flow cytometry, identify which dot plots represent the healthy control and patient samples in each scenario and come up with a clinical diagnosis. Note that you may need to use additional background sources to fully understand what is going on at the cellular level for each diagnosis. What is the clinical diagnosis Chronic Ⓒleukaemia CD14-PE CD3-APC CD3-APC CD14-PE 20% 5% 15% 4% 29% NES 8% 42% 7% O Sepsis O CD16-FITC CD15-FITC CD15-FITC CD16-FITC Chronic Myelomonocytic Leukaemia 25% 50% 81% 63% 17% 34% CD8-PE CD3-APC CD3-APC CD8-PE 27% 5% 6% 2% 0.3% 99% Severe Combined Immunodeficiency CD4-V500 CD45-PE CD45-PE CD4-V500 Select the flow cytometry dot plot that corresponds to the patient sample 68% 22% 72% 50% Select the flow cytometry dot plot that corresponds to the healthy control sample 48% 0.1% 0.6%
You are presented with the following clinical scenario: "A 50 year old patient presents with fatigue, night sweats and weight loss. Flow cytometry shows increased numbers of immature leukocytes." Using your knowledge of immunology and flow cytometry, identify which dot plots represent the healthy control and patient samples in each scenario and come up with a clinical diagnosis. Note that you may need to use additional background sources to fully understand what is going on at the cellular level for each diagnosis. What is the clinical diagnosis Chronic Ⓒleukaemia CD14-PE CD3-APC CD3-APC CD14-PE 20% 5% 15% 4% 29% NES 8% 42% 7% O Sepsis O CD16-FITC CD15-FITC CD15-FITC CD16-FITC Chronic Myelomonocytic Leukaemia 25% 50% 81% 63% 17% 34% CD8-PE CD3-APC CD3-APC CD8-PE 27% 5% 6% 2% 0.3% 99% Severe Combined Immunodeficiency CD4-V500 CD45-PE CD45-PE CD4-V500 Select the flow cytometry dot plot that corresponds to the patient sample 68% 22% 72% 50% Select the flow cytometry dot plot that corresponds to the healthy control sample 48% 0.1% 0.6%
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Transcribed Image Text:You are presented with the following clinical scenario:
"A 50 year old patient presents with fatigue, night sweats and weight loss. Flow cytometry shows increased numbers
of immature leukocytes."
Using your knowledge of immunology and flow cytometry, identify which dot plots represent the healthy control and
patient samples in each scenario and come up with a clinical diagnosis. Note that you may need to use additional
background sources to fully understand what is going on at the cellular level for each diagnosis.
What is the clinical diagnosis
Chronic
Ⓒleukaemia
CD14-PE
CD3-APC
CD3-APC
CD14-PE
20%
5%
15%
4%
29%
NES
8%
42%
7%
O Sepsis O
CD16-FITC
CD15-FITC
CD15-FITC
CD16-FITC
Chronic Myelomonocytic
Leukaemia
25%
50%
81%
63%
17%
34%
CD8-PE
CD3-APC
CD3-APC
CD8-PE
27%
5%
6%
2%
0.3%
99%
Severe Combined
Immunodeficiency
CD4-V500
CD45-PE
CD45-PE
CD4-V500
Select the flow cytometry dot plot that corresponds to the patient sample
68%
22%
72%
50%
Select the flow cytometry dot plot that corresponds to the healthy control sample
48%
0.1%
0.6%
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