You are running a travel clinic with your pharmacy and as an independent prescriber you can write prescriptions for malarial prophylaxis. Within your clinic, you use the maximum recommended treatment length for all courses. A family of two are travelling to Ghana for 14 days. The most recent weights of the family members are shown below. Mum: 54kg Child 1: 27kg Below are the prices that you charge each of the drugs that are suitable for this family. They can either all take Lariam or the Malarone/Malarone Paediatric Lariam tabs £14.48 per pack (8 tablets) Malarone £25.20 per pack (12 tablets) Malarone Paediatric £6.24 per pack (12 tablets) Using the information available to you and the relevant SPC (at the end of the worksheet), calculate the price difference between the two regimens. (Give your answer to the nearest pound) (Lariam 250 mg tablets) Active ingredient -mefloquine hydrochloride Legal Category - POM: Prescription only medicine 4.2 Posology and method of administration Chemoprophylaxis For malaria prophylaxis the stated dose of Lariam should be given once weekly, always on the same day. In order to ensure, before arrival in endemic area, that Lariam administration is well tolerated, it is recommended to start chemoprophylaxis with Lariam 10 days before departure (i.e. first intake 10 days before departure and 2nd intake 3 days before departure). Subsequent doses should be taken once a week (on a fixed day). Treatment should be continued for 4 weeks after leaving a malarious area (minimum treatment period 6 weeks). The maximum recommended duration of administration of Lariam is 12 months. The recommended chemoprophylactic dose of Lariam is approximately 5 mg/kg bodyweight once weekly. The following dosage schedule is given as a guide: Adults and children of more than 45 kg bodyweight 1 tablet Children and adults weighing less than 45 kg 5 – 19 kg ¼ tablet 1/ 4 tablet 20 – 30 kg ½ tablet 1/ 4 tablet 31 – 45 kg ¾ tablet 3/ 4 tablet The tablets should be swallowed whole preferably after a meal with plenty of liquid

Curren'S Math For Meds: Dosages & Sol
11th Edition
ISBN:9781305143531
Author:CURREN
Publisher:CURREN
Chapter16: Adult And Pediatric Dosages Based On Body Surface Area
Section: Chapter Questions
Problem 5.3P
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You are running a travel clinic with your pharmacy and as an independent 
prescriber you can write prescriptions for malarial prophylaxis. Within your clinic, 
you use the maximum recommended treatment length for all courses. 
A family of two are travelling to Ghana for 14 days. The most recent weights 
of the family members are shown below.

Mum: 54kg
Child 1: 27kg


Below are the prices that you charge each of the drugs that are suitable for this family. They 
can either all take Lariam or the Malarone/Malarone Paediatric

Lariam tabs £14.48 per pack (8 tablets)
Malarone £25.20 per pack (12 tablets)
Malarone Paediatric £6.24 per pack (12 tablets)

Using the information available to you and the relevant SPC (at the end of the worksheet), calculate the price difference between the two regimens. (Give your answer to the nearest pound)

 

(Lariam 250 mg tablets)


Active ingredient      -mefloquine hydrochloride
Legal Category       - POM: Prescription only medicine

4.2 Posology and method of administration
Chemoprophylaxis
For malaria prophylaxis the stated dose of Lariam should be given once weekly, always on the same day.
In order to ensure, before arrival in endemic area, that Lariam administration is well tolerated, it is 
recommended to start chemoprophylaxis with Lariam 10 days before departure (i.e. first intake 10 days 
before departure and 2nd intake 3 days before departure). Subsequent doses should be taken once a 
week (on a fixed day).
Treatment should be continued for 4 weeks after leaving a malarious area (minimum treatment period 6 
weeks). The maximum recommended duration of administration of Lariam is 12 months.
The recommended chemoprophylactic dose of Lariam is approximately 5 mg/kg bodyweight once weekly. 
The following dosage schedule is given as a guide: 


Adults and children of more than 45 kg bodyweight  1 tablet
Children and adults weighing less than 45 kg
5 – 19 kg ¼ tablet 1/ 4 tablet
20 – 30 kg ½ tablet 1/ 4 tablet
31 – 45 kg ¾ tablet 3/ 4 tablet


The tablets should be swallowed whole preferably after a meal with plenty of liquid

Malarone Paediatric Tablets
4.2 Posology and method of administration
Method of administration
The daily dose should be taken once daily with food or a
milky drink (to ensure maximum absorption) at the same
time each day.
If patients are unable to tolerate food Malarone
paediatric tablets should be administered, but systemic
exposure of atovaquone will be reduced. In the event of
vomiting within 1-hour of dosing a repeat dose should
be taken.
Malarone paediatric tablets should preferably be
swallowed whole. If difficulties are encountered when
dosing young children, the tablets may be crushed and
mixed with food or a milky drink just prior to
administration.
Posology
The dosage for the prophylaxis and treatment of acute,
uncomplicated P. falciparum malaria in children is based
on body weight.
Prophylaxis
Dosage in individuals weighing 11-40 kg
Dosage/day
No of Tablets
Body Weight
Range (kg)
Atovaquone
(mg)
Proguanil
(mg)
One Malarone paediatric tablet
Two Malarone paediatric tablets
Three Malarone paediatric tablet
Subjects of >40 kg should receive ONE Malarone
250/100 mg tablet daily
Refer to Malarone 250/100 mg Tablets SMPC
11-20
62.5
25
21-30
125
50
31-40
187.5
75
>40
250
100
Prophylaxis should
• commence 24 or 48 hours prior to entering a malaria-
endemic area,
continue during the period of the stay,
• continue for 7 days after leaving the area.
Transcribed Image Text:Malarone Paediatric Tablets 4.2 Posology and method of administration Method of administration The daily dose should be taken once daily with food or a milky drink (to ensure maximum absorption) at the same time each day. If patients are unable to tolerate food Malarone paediatric tablets should be administered, but systemic exposure of atovaquone will be reduced. In the event of vomiting within 1-hour of dosing a repeat dose should be taken. Malarone paediatric tablets should preferably be swallowed whole. If difficulties are encountered when dosing young children, the tablets may be crushed and mixed with food or a milky drink just prior to administration. Posology The dosage for the prophylaxis and treatment of acute, uncomplicated P. falciparum malaria in children is based on body weight. Prophylaxis Dosage in individuals weighing 11-40 kg Dosage/day No of Tablets Body Weight Range (kg) Atovaquone (mg) Proguanil (mg) One Malarone paediatric tablet Two Malarone paediatric tablets Three Malarone paediatric tablet Subjects of >40 kg should receive ONE Malarone 250/100 mg tablet daily Refer to Malarone 250/100 mg Tablets SMPC 11-20 62.5 25 21-30 125 50 31-40 187.5 75 >40 250 100 Prophylaxis should • commence 24 or 48 hours prior to entering a malaria- endemic area, continue during the period of the stay, • continue for 7 days after leaving the area.
Malarone
4.2 Posology and method of administration
Method of administration
The daily dose should be taken with food or a milky
drink (to ensure maximum absorption) at the same time
each day.
If patients are unable to tolerate food, Malarone should
be administered, but systemic exposure of atovaquone
will be reduced. In the event of vomiting within 1 hour of
dosing a repeat dose should be taken.
Posology.
Prophylaxis:
Prophylaxis should
• commence 24 or 48 hours prior to entering a malaria-
endemic area,
• continue during the period of the stay
• continue for 7 days after leaving the area.
In residents (semi-immune subjects) of endemic areas,
the safety and effectiveness of Malarone has been
established in studies of up to 12 weeks.
In non-immune subjects, the average duration of
exposure in clinical studies was 27 days.
Dosage in Adults
One Malarone tablet daily.
Malarone tablets are not recommended for malaria
prophylaxis in persons under 40 kg bodyweight.
Malarone paediatric tablets are recommended for
malaria prophylaxis in persons weighing <40 kg
Transcribed Image Text:Malarone 4.2 Posology and method of administration Method of administration The daily dose should be taken with food or a milky drink (to ensure maximum absorption) at the same time each day. If patients are unable to tolerate food, Malarone should be administered, but systemic exposure of atovaquone will be reduced. In the event of vomiting within 1 hour of dosing a repeat dose should be taken. Posology. Prophylaxis: Prophylaxis should • commence 24 or 48 hours prior to entering a malaria- endemic area, • continue during the period of the stay • continue for 7 days after leaving the area. In residents (semi-immune subjects) of endemic areas, the safety and effectiveness of Malarone has been established in studies of up to 12 weeks. In non-immune subjects, the average duration of exposure in clinical studies was 27 days. Dosage in Adults One Malarone tablet daily. Malarone tablets are not recommended for malaria prophylaxis in persons under 40 kg bodyweight. Malarone paediatric tablets are recommended for malaria prophylaxis in persons weighing <40 kg
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