You have in your possession five mouse strains. The mice of each strain lack a specific gene (i.e., they are gene- knockout animals). • Strain A: Mice are unable to generate an & heavy chain. • Strain B: Mice are unable to generate a high-affinity FCERI receptor. • Strain C: Mice are unable to generate a low-affinity FCERII receptor. • Strain D: Mice are deficient in the ability to generate the complement attack complex. ⚫ Strain E: Mice are unable to express CD21. Assign each description to one or more mouse strains to explain how type I and type II hypersensitivity responses differ from wild-type mice. Unable to generate an ε heavy chain. Unable to generate a high-affinity FCεRI receptor. Answer Bank There might be a type I response but it might be abnormal. Unable to generate a low-affinity FcεRII receptor. Deficient in the ability to generate the complement attack complex. Unable to express CD21. There might be a type II response but it might be supressed. There will be a type II response mediated by IgG or IgM. There will be no type II response. There will be no type I response. There will be a type I response mediated by IgE interactions.
You have in your possession five mouse strains. The mice of each strain lack a specific gene (i.e., they are gene- knockout animals). • Strain A: Mice are unable to generate an & heavy chain. • Strain B: Mice are unable to generate a high-affinity FCERI receptor. • Strain C: Mice are unable to generate a low-affinity FCERII receptor. • Strain D: Mice are deficient in the ability to generate the complement attack complex. ⚫ Strain E: Mice are unable to express CD21. Assign each description to one or more mouse strains to explain how type I and type II hypersensitivity responses differ from wild-type mice. Unable to generate an ε heavy chain. Unable to generate a high-affinity FCεRI receptor. Answer Bank There might be a type I response but it might be abnormal. Unable to generate a low-affinity FcεRII receptor. Deficient in the ability to generate the complement attack complex. Unable to express CD21. There might be a type II response but it might be supressed. There will be a type II response mediated by IgG or IgM. There will be no type II response. There will be no type I response. There will be a type I response mediated by IgE interactions.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
Related questions
Question
Ch 15 Allergy, hypersensitivities, and chronic inflammation: Kuby Immunology book material
![You have in your possession five mouse strains. The mice of each strain lack a specific gene (i.e., they are gene-
knockout animals).
• Strain A: Mice are unable to generate an & heavy chain.
• Strain B: Mice are unable to generate a high-affinity FCERI receptor.
• Strain C: Mice are unable to generate a low-affinity FCERII receptor.
• Strain D: Mice are deficient in the ability to generate the complement attack complex.
⚫ Strain E: Mice are unable to express CD21.
Assign each description to one or more mouse strains to explain how type I and type II hypersensitivity responses differ from
wild-type mice.
Unable to generate an ε heavy chain.
Unable to generate a
high-affinity FCεRI receptor.
Answer Bank
There might be a type I
response but it might
be abnormal.
Unable to generate a
low-affinity FcεRII receptor.
Deficient in the ability to generate
the complement attack complex.
Unable to express CD21.
There might be a type II
response but it might
be supressed.
There will be a type II
response mediated by IgG
or IgM.
There will be no type
II response.
There will be no type
I response.
There will be a type I
response mediated by
IgE interactions.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fc3eb3c55-3996-4e07-93a0-a3410210cd33%2F0322c8af-0a59-4952-a589-ef8aedd424ef%2Fkni2mxu_processed.png&w=3840&q=75)
Transcribed Image Text:You have in your possession five mouse strains. The mice of each strain lack a specific gene (i.e., they are gene-
knockout animals).
• Strain A: Mice are unable to generate an & heavy chain.
• Strain B: Mice are unable to generate a high-affinity FCERI receptor.
• Strain C: Mice are unable to generate a low-affinity FCERII receptor.
• Strain D: Mice are deficient in the ability to generate the complement attack complex.
⚫ Strain E: Mice are unable to express CD21.
Assign each description to one or more mouse strains to explain how type I and type II hypersensitivity responses differ from
wild-type mice.
Unable to generate an ε heavy chain.
Unable to generate a
high-affinity FCεRI receptor.
Answer Bank
There might be a type I
response but it might
be abnormal.
Unable to generate a
low-affinity FcεRII receptor.
Deficient in the ability to generate
the complement attack complex.
Unable to express CD21.
There might be a type II
response but it might
be supressed.
There will be a type II
response mediated by IgG
or IgM.
There will be no type
II response.
There will be no type
I response.
There will be a type I
response mediated by
IgE interactions.
Expert Solution
![](/static/compass_v2/shared-icons/check-mark.png)
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
Step by step
Solved in 2 steps
![Blurred answer](/static/compass_v2/solution-images/blurred-answer.jpg)
Recommended textbooks for you
![Human Anatomy & Physiology (11th Edition)](https://www.bartleby.com/isbn_cover_images/9780134580999/9780134580999_smallCoverImage.gif)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
![Biology 2e](https://www.bartleby.com/isbn_cover_images/9781947172517/9781947172517_coverImage_Textbooks.gif)
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
![Anatomy & Physiology](https://www.bartleby.com/isbn_cover_images/9781259398629/9781259398629_smallCoverImage.gif)
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
![Human Anatomy & Physiology (11th Edition)](https://www.bartleby.com/isbn_cover_images/9780134580999/9780134580999_smallCoverImage.gif)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
![Biology 2e](https://www.bartleby.com/isbn_cover_images/9781947172517/9781947172517_coverImage_Textbooks.gif)
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
![Anatomy & Physiology](https://www.bartleby.com/isbn_cover_images/9781259398629/9781259398629_smallCoverImage.gif)
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
![Molecular Biology of the Cell (Sixth Edition)](https://www.bartleby.com/isbn_cover_images/9780815344322/9780815344322_smallCoverImage.gif)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
![Laboratory Manual For Human Anatomy & Physiology](https://www.bartleby.com/isbn_cover_images/9781260159363/9781260159363_smallCoverImage.gif)
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
![Inquiry Into Life (16th Edition)](https://www.bartleby.com/isbn_cover_images/9781260231700/9781260231700_smallCoverImage.gif)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education