Hepatology

Summary •Allergan’s (AGN) September 20th purchase of NASH treatment pharmaceutical companies Tobira ($1.7 billion) and Akarna ($50 million) left many investors wondering about the disease’s market potential and major players. • There are currently no approved treatments for NASH; the prevalence of the disease increases each year, and the annual market could be massive • Slingshot Insights will host an Expert Interview intended to better understand NASH and the key companies developing treatments

RESEARCH ARTICLE Portal vein thrombosis in patients with liver cirrhosis Insights to risk factors, clinical presentation and outcome Afifi F. Afifi 1 , Usama M. Basha 1 , Fady M. Wadea 1 , Abdelaziz E. Samack 2 , Raghda A. Elsherbini 3 1- GIT and hepatology unit, internal medicine department, faculty of medicine, zagazig university. 2- radiology department, faculty of medicine, zagazig university. 3- clinical pathology department, faculty of medicine, zagazig university. EGYPT Manuscript Info Abstract

Running head: Liver biopsy 1 Liver biopsy guided by ultrasound (US) versus computed tomography (CT) Faisal Haq ECPI University Abstract Liver biopsy guided by ultrasound (US) versus computed tomography (CT) ​Liver disease is one of the leading causes of death in the United States with the mortality rate of 38

Obstetric Cholestasis (OC) or Intraheptic Cholestasis of pregnancy is a disorder that is unique to pregnancy (Kelly and Nelson-Piercy, 2000).OC classically presents in the third trimester (Royal College of Obstetricians and Gynaecologists [RCOG], 2006), With maternal pruritus and raised bile acids (Geenes and Williamson, 2009).It is one of the few disorders of pregnancy that can affect both maternal well being and fetal outcome. OC usually resolves forty eight hours after delivery (Mays, 2010).

Page 8 Page 9 ISSN 2320-5407 International Journal of Advanced Research (2015), Volume 3, Issue 12, 1539 –15481546INR levels were less in PVT group than control group but in patients with early stages of liver cirrhosis, no differences in their levels was found between the 2 groups. Therefore, patients with advanced liver cirrhosis and less prolonged coagulation parameters appear to carry a higher risk of PVT compared with patients with advanced liver cirrhosis

A study was conducted to determine , Non-alcoholic fatty liver disease and its histological scoring systems. Non-alcoholic fatty liver disease (NAFLD) is an increasingly common cause of chronic liver disease. The study says that the incidence of recurrent steatosis in patients transplanted for cryptogenic cirrhosis or NASH-cirrhosis ranges from 25%-100%, while NASH development is observed in 10%-37.5% of these cases without leading to early allograft failure. The ongoing discussions of the limits

RESEARCHRESEARCH ARTICLEPortal vein thrombosis in patients with liver cirrhosis:insights to risk factors, clinical presentation and outcomeAfifi F. Afifi 1, Osama M. Basha 1, Fady M. Wadea 1, Abdelaziz E. Samack 2, Raghda Abd-elatif Hafez31-GIT and hepatology unit, Internal Medicine department, Faculty of Medicine, Zagazig University.2-Radiology department, Faculty of Medicine, Zagazig University.3-Microbiology&Immunologydepartment, Faculty of Medicine, Zagazig University. EGYPTManuscriptInfoAbstract

Portal vein thrombosis in patients with liver cirrhosis: insights to risk factors, clinical presentation and outcome Afifi F. Afifi 1, Osama M. Basha 1 , Fady M. Wadea 1, Abdelaziz E. Samack 2, Raghda Abd-elatif Hafez 3 1- GIT and hepatology unit, Internal Medicine department, Faculty of Medicine, Zagazig University. 2- Radiology department, Faculty of Medicine, Zagazig University. 3- Microbiology&Immunology department, Faculty of Medicine, Zagazig University. EGYPT Manuscript Info Abstract

The higher risk of surgery in a cirrhotic patient is due to the fact that the liver normally performs myriad metabolic and synthetic functions in the body. The liver is vital for protein synthesis, coagulation homeostasis, glucose homeostasis, bilirubin excretion, drug metabolism, and toxin removal, among other critical functions. The optimal management of a cirrhotic patient for elective total hip replacement surgery would involve: 1. Pre- operative assessment, including a detailed history, examination

Introduce your selected leading cause of death and state why this was chosen. According to the American Liver Foundation, a healthy liver cleans blood, fights infection processes food and stores energy. The liver is able to regenerate itself, but when it becomes too damaged or is prevented from regenerating, it will fail and no longer be able to keep able to keep one alive (2015). Despite its ability to regenerate, chronic liver disease and cirrhosis is the twelfth leading cause of death of death