Metabolomics

Metabolomics: A field of life science research that uses high throughput (HT) technologies to identify and or characterized all the small molecules or metabolites in a given cell, tissue or organ (I.e. the metabolite). Metabolite: Any natural atom discernible in the body with the sub-atomic weight (MW) under 1500 Dalton's. It incorporates liveliness tides, oligonucleotides, sugars, nucleosides, natural acids, ketones, aldehydes, amines, amino acids, steroids, alkaloids, nourishment added substances

implemented for metabolomics studies NMR provides several advantages. Firstly, NMR-based metabolic profiling can be highly quantitative and reproducible. This is extremely helpful when multivariate analysis are usually performed in metabolomic analysis (Nicholson and Wilson 1989). Furthermore, NMR sensitivity is hardly affected by metabolite pKa or hydrophobicity, which suggests that NMR is an excellent choice for samples in different conditions (Pan and Raftery 2007). In many metabolomics studies, e

Metabolomics approaches in depression Zheng and colleges conducted ¹H NMR metabolomic study of plasma of patients with Major Depressive Disorder (MDD) [82]. Samples of 58 first-episode naïve depressive patients and 52 healthy volunteers were investigated. Results demonstrated that the groups were significantly distinguishable. What is more, the method allowed identification of blind samples (n=26). The study presents the platform applied as a potential empirical and laboratory method for MDD diagnosis

3.1 RPLC analysis identifies unique metabolomics profiles of SD disease Untargeted metabolomics profiling of liver and brain samples from SD mice (n=3) and normal mice (n=3) were performed through RPLC. A total of 177 metabolites were found to be significantly dysregulated in mouse liver samples (p (-- removed HTML --) 0.5). Out of these 177 metabolites, 96 (54.2%) out were significantly upregulated, while 81 (45.8%) were downregulated in SD mouse liver. Similarly, a total of 112 metabolites were

resuscitated with different oxygen concentrations [12]. A recent metabolomics analysis of urine has shown the gestational age related differences in metabolic profiles of phenylalanine and tryptophan biosynthesis, urea cycle, tyrosine metabolism, arginine and proline metabolism [8]. The differences in neonates with IUGR and normal controls have been found in urinary metabolic profiles of myo-inositol, sarcosine and creatinine [29]. Recently, a metabolomic analysis of urine has shown to identify the children

The Whitehead Institute for Biomedical Research at MIT recently published a new study in which the molecular activity of a critical protein is elucidated in depth. A research team at Whitehead used metabolomics technology to accomplish this, analyzing a protein known to be responsible for making plants resistant to herbicide. The team found that the protein is occasionally inaccurate, and another team also found a means by which to re-engineer them to be more accurate at the University of Zurich

I have started my research with applied probability in theoretical population biology and in statistical genetics during my PhD. However, during my postdoctoral work at the Emory University I started working in a completely different topic of developing HIV vaccine trial design and survival analysis. Soon afterwards during the early days of my Assistant Professorship at Georgia State University, I got exposed to an exciting field of research microarray data analysis. I found it to be fascinating

Automated Drug Repurposing Based on ‘Omics’ Data Mining Dylan T. Lehrer College of Saint Benedict and Saint John’s University October 14, 2016 Automated Drug Repurposing Based on ‘Omics’ Data Mining by Dylan Lehrer Approved by: Dr. Imad Rahal Associate Professor of Computer Science Dr. Manuel Campos Professor of Biology Dr. Rasanjalee Dissanayaka Assistant Professor of Computer Science Dr. Imad Rahal Chair, Department of Computer Science Dr. Emily Esch Director, All College Thesis

More dysregulated metabolites were identified in the liver (n=177) than that in the brain (n=122). Notably, there are more amino acid, amino acid derivatives and dipeptides identified in livers (mostly upregulated). These results are expected because the liver is the primary site of metabolism. In terms of pathways enriched, significant involvement of neurotransmission and chemical synaptic transmission were observed in the brain. Meanwhile, there are several pathways only enriched in livers, including

Bacteria in some ways are very similar to humans. I wonder, like humans, if music affects bacterial growth and productivity. A German waste treatment facility is using Mozart to help speed up the facility's sewage eating microbes.This method of waste treatment was first started by Anton Stucki, a german company executive. “The sonic waves of Mozart's compositions, along with the addition of oxygen, spur micro-organisms to a higher performance in breaking down biosolids, Stucki explained(spiegel online