PAX6

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    Pax6 is a transcription gene it functions as a regulatory gene transcription, and plays a key role in the development of the eye during embryonic development. Because Pax6 is a transcription factor gene to ensure that there is proper development, it has the ability activate or deactivate gene expression. That being said Pax6 acts a master control gene as stated before for the development of the eye and other sensory organs. There are more functions for the Pax6 gene, but I will be focusing more on

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    importance of Pax6’s discovery, mutations, and signaling pathway will be emphasized. It is worthy to note that Pax6 does not operate in a hierarchical linear signaling pathway but instead, in a massive network with numerous feedback loops. It is impossible to cover all possible feedback loops; therefore, the focus of the signaling pathway will be on the lens placode. The Pax6 gene was originally found in D. melanogaster corresponding to the eyeless locus (Mansouri et al. 1996). While Pax6 is most famous

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    and other chemicals in the organism’s body. Through tracking the evolution of chemicals a person can see how close two organisms are related. This method of tracking is useful with proteins like Pax6 a gene that controls eye development. Organisms that have an eyes can be found to have a variation of Pax6, these organisms include mice, humans, flies,

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    The Developmental Eye Disorders of Anophthalmia and Microphthalmia The development of the human body is an exquisite process that involves numerous complicated processes for even the smallest of body parts, including the eyes. The eyes are an extraordinarily complex organ capable of gathering information through refracted light and sending it the brain to assemble a picture. They provide the ability to see and follow a moving object and the capability to tell an approximate distance of an object

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    Explain the reasoning behind this statement and provide support for it. - We can see that Homeotic Genes do work to make any animal form because it is the same in each animal. A great example of this is the work by Walter Gehring in which he used the Pax6 gene from a mouse to code for eyes in a fruit fly which proved to be successful. This provided evidence that the genes, also known as the homeotic or “tool kit” genes are

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    Aniridia Research Paper

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    an extreme form of Iris Hypoplasia (the underdevelopment of the iris or colored part of the eye). Aniridia runs in families, you're born with it and it occurs in both eyes. The Greek meaning of Aniridia is "without iris". Aniridia is caused by the Pax6 gene. This gene is responsible for eye development and when it doesn't function correctly the eye stops developing too early and this causes the baby to be born with underdeveloped eyes. Eyes that are affected by Aniridia look like the pupil is extremely

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    Mei Yun Lin Quiz for GS616 - Genetics discussion section – Short Answers 20 points total (2/2 points) 1) What is a loss-of-function experiment? Loss of function experiments, such as in a gene knockout experiment, in which an organism is engineered to lack the activity of one or more genes, resulted in gene product to have less or no function. It is very commonly used in the research, and it can reduce or abolish protein function. (3/3 points) 1) What is a gain-of-function experiment? Gain

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    Olfactory Paper

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    LEHMAN COLLEGE BIO 320: NEURAL DEVELOPMENT December 22nd, 2015 ABDUL BAIS AHMED Problem: Role of Retinoic acid in central nervous development Olfactory neurons are chemosensory neurons whose role is fulfilled by maintaining direct contact with the outside environment, which sometimes expose them to harm. As a result, there is the need to have a source of progenitor to replenish the damaged cells. It’s widely known that olfactory epithelium (OE) regenerates and replaces damaged olfactory neurons

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    generated mutation is unique or has been previously described. To perform the analysis, I would mate the mutants I produced with known mouse lines which have null mutations in genes known to be important for DA neuron axon guidance (DCC-/-, Nkx2.1-/-, Pax6-/-, Slit1-/-, Robo1-/- ). If WT phenotype is produced by the cross, the mutations are in 2 different genes. If the offspring shows mutant phenotype, the mutation might occur in the same gene (Hegarty, Sullivan et al. 2013). 5. Perform linkage analysis

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    Embryonic Neurogenesis

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    The advances that have been made over the last two decades in stem cell research have changed the field of neuroscience. The field has gained a better understanding of the influence of transcription factors on regulating cell fate as well as other genetic, epigenetic, and environment factors. It has also advanced our understanding of embryonic neurogenesis as well as resolved some of the controversy in adult neurogenesis. In this review several of the identified intrinsic and extrinsic factors that

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