the rat spinal cord. The aim of this study was to functionally characterize receptors for Amylin and Salmon Calcitonin in the spinal cord of rats. We assessed the expression of c-fos in response to intraplantar formalin in the lumbar regions of spinal cord in conscious rats. Methods: Amylin (0.05nmoles) or Salmon Calcitonin (0.005nmoles) were administrated intrathecally) 10 min before the start of formalin test. Antagonists were injected intrathecally 10min before the administration of either of the
Following considerable deliberation, the World Health Organisation (WHO) has classified PAH into five major diagnostic categories (Table 1)(1). Currently there are several pharmacological treatment options for PAH which include endothelial receptor antagonists (ERA), calcium-channels blockers, prostanoids and phosphodiesterase type 5 inhibitors (PDE5). Nevertheless, novel therapies are still in development.
presence of antagonist, the NCA mechanism will show decrease in max contraction of agonist with presence of antagonist, and physiological antagonism will show relaxation of tissue due to the action of antagonist during presence of agonist. Each agonist
Lysergic Acid Diethlyamide The psychedelic effects of d-Lysergic Acid Diethylamide-25 (LSD) were discovered by Dr. Albert Hoffman by accident in 1938. In the 1950s and 1960s, LSD was used by psychiatrists for analytic psychotherapy. It was thought that the administration of LSD could aid the patient in releasing repressed material. It was also suggested that psychiatrists themselves might develop more insight into the pathology of a diseased mind through self experimentation. 1,2 During the late
GPCRs are important for receptor function. They contribute to protein folding, provide structure to the extracellular region and mediate movement of the TM helices on activation. The second extracellular loop (ECL2) is of significance for ligand binding and receptor activation. In family B (or secretin-like) GPCRs, it is the most conserved and often the longest of all the ECLs, and so is in a good position to interact with the endogenous peptide agonists for these receptors and is in a prominent central
we can thus assume that A is a full agonist. Drug B: When the cells were exposed to drug B at two different concentrations (10uM and 10 µM), no change in activity was noticed and it was equal to basal activity. This clearly signals that B is an antagonist. Then we examine the effect of drug B when used in combination with drug A. The amount of cyclic AMP has decreased as the concentration of drug B increased from 10 uM to 10 µM while the concentration
A 5-HT2A receptor antagonist blocked the social effects of MDMA. A 5-HT2C agonist decreased huddling but did not affect social vocalizations, and a 5-HT1A agonist decreased huddling (Pitts et al., 2017). The researchers concluded that MDMA and its enantiomers increase the frequency of affiliative behaviors and vocalizations in a dose-dependent fashion, and the behavioral effects of MDMA are 5-HT2A receptor dependent (Pitts et al., 2017). This study has many
Ketamine is a narcotic medication prescribed as an anesthetic agent and an analgesic. The articles argue for adding broadening Ketamine 's therapeutic boundaries in relation to what is legally prescribed in the U.S.A. Specifically, broadening to include Ketamine as an anti-depressive treatment. The difference between these articles lie in what ways Ketamine is perceived as a useful antidepressant and how those conclusions are formed. I chose this topic because I am a certified Pharmacy Technician
Discuss how cutting-edge scientific discoveries may provide potential therapies for Schizophrenia Schizophrenia is a long-term, psychotic disorder that affects approximately 1% of the world’s population (Dourish and Dawson, 2014). The condition is characterised by a ‘fundamental disturbance of personality’, as a person suffers from hallucinations (either hearing voices or seeing things that do not exist), delusions, altered perceptions and an overall, quite dramatic, change in behaviour (Tsuang
5-HT3 RECEPTOR ANTAGONISTS: MODULATOR OF ABUSE POTENTIAL OF DRUGS Abstract Serotonergic system in brain creates an important network for proper functioning of brain. It plays an integral role in regulating A9 as well as A10 dopaminergic neurons in basal neuronal circuit. The 5-HT3 receptors are found to be the only ionic receptors in serotonergic family of receptors regulating several important functions of brain. The abuse drugs lead to dopamine increase in nucleus accumbens. This paper reflects