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Alzheimer's Disease Study

Decent Essays
Alzheimer's disease is a devastating disorder of the brain, it is the most common cause of dementia, and the leading cause of death in women in the UK (Gallagher, 2014). Alzheimers is a progressive neurodegenerative disease, that occurs in a middle to old age person. Its symptoms slowly deteriorate the brains functions until it eventually results in death. The most common symptom of Alzheimers disease is progressive memory loss. As the disease progresses patients begin to demonstrate poor judgment and their inability to take carry out daily tasks. They develop a strong sense of confusion not recognising familiar people, places or things in their lives and soon develop problems with speech/language and frequent changes in mood. At this point,…show more content…
It is vital for scientists to study the disease and its progression to fully understand it and find a means of treating it. Traditionally scientist use primary neuronal cultures to study Alzheimer’s. However this method is very expensive and quite time consuming (Ray et al., 2014). The process for a primary neuronal culture from a mouse or rat is quite an extensive procedure. Prior to carrying out the experiment 19 to 21 days are needed to breed an embryo. At the late embryonic stage of the pregnancy, the embryo within the pregnant mouse is dissected out of its mother to be used in the lab (Seibenhener and Wooten, 2012). Anaesthesia is not used during this process as it is known to cause brain cell death (Jevtovic-Todorovic et al. 2003). From this point the embryo is removed and then cut into to remove its brain, more specifically a part of the hippocampus to be cultured (Seibenhener and Wooten, 2012). This type of procedure is unethical to mice, time consuming as well as expensive. In addition various reports have stated that primary neuronal cultures are not a very accurate method of studying Alzheimers disease because of certain limitations. For example it is quite difficult to study the true physiological functions of the brain and the disease in isolated primary neuronal culture (Xiong and Gendelman, 2014). It is challenging for scientists to observe the true state of a neuronal…show more content…
Various laboratory systems will be looked into, to observe if any are truly successful in mimicking the neuronal functions needed to properly study Alzheimers. The laboratory systems will mainly concentrate on in-vitro models of studying Alzheimers disease such induced pluripotent stem cells, frozen immortal cell lines and post mortem tissue cell lines derived from Alzheimer patients. However the in vivo model of drosophila will also be looked into as an alternative as opposed to primary neuronal cultures. All the information gathered from both in vitro and in vivo laboratory systems will be used to form a criteria in order to compare and contrast which method can produce the best results in terms of studying Alzheimers. It is important to invest in an alternative method that will produce more accurate results and avoid unethical, and costly experiments. The number of people diagnosed with Alzheimers disease is only continuing to increase and in years time the amount of people affected world wide will be doubled todays. The disease will not only take a massive toll on the people affected but their families and carers. Unfortunately Alzheimers is a very costly disease and will soon burden the health care industry (Prübing et al., 2013). After undergoing this research, hopefully there is a positive outcome, that
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