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Antiviral Drug Susceptibility of Influenza Viruses Essay

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Descriptive statistics was used in the research studies of the annotated bibliographies below and provides data that can be applied to the treatment of individuals possibly infected with the influenza virus. The data collected from specific populations shows the effects of specific antiviral drugs under certain conditions. Use of the data will enable healthcare providers to select the best course of action and determine proper use of limited resources in today’s cost constrained environment.
Hypothesis
Using a selected location in the United States with a large population exposed to both seasonal and pandemic influenza strains given antiviral medications, examination of the population’s resistance to projected influenza strains
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The study used a single intramuscular injection with a variety of dosages of the drugs Peramivir, Zanamivir, and Oseltamivir (Tamiflu) in mice infected with the H1N1 influenza virus that caused the 2009 Pandemic in the United States. The study used the mean day of death that the average number of days that the mice survived following infection with H1N1. Evaluation of the weight loss differences in the mice of the study was performed using a one-way analysis of variance (ANOVA). The mice in the study experience weight loss and mortality following H1N1 infection therefore efficacy of the antivirals was evaluated on weight loss per mouse and mean day to the death of the mice. Mice injected with Peramivir showed better survivability rates than those receiving the same dosages of Zanamivir, and Oseltamivir (Tamiflu) when initially infected with the H1N1 influenza virus. Support of our hypothesis is seen by noting that during the pandemic of 2009 Oseltamivir (Tamiflu) was the initial drug of choice and treated people infected with H1N1 successfully. However as the pandemic spread across the United States antiviral resistance was noted as increasing commensurate with the number of days the pandemic raged. The strains used to infect the mice in the study were the later strains collected at the end of the 2009 pandemic where the Oseltamivir (Tamiflu) resistance was initially noted. No significant increases of antiviral resistance were noted
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