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Atomoxetine Research Paper

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Atomoxetine Stimulant medication for ADHD has evidence for safety and efficacy, however this does not rule out 30% of the population that does not respond to stimulants. Non-stimulants are very useful in these situations. Atomoxetine (ATM) is a norepinephrine transport inhibitor and was the first non-stimulant to be approved for use in ADHD. The daily recommended dose for children is 1.4mg/kg. The exact mechanism of action is unknown for ATM, however research suggests it is a selective inhibitor of presynaptic NOR transporters, therefore inhibiting reuptake of norepinephrine. Primarily, the CYP2D6 isoenzyme pathway hepatically metabolizes ATM and undergoes oxidation, forming the active metabolite 4-hydroxatomoxetine. The second metabolite

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