Bacopa Monnieri In Cancer

An example of those are carnosic acid, rosmarinic acid and caffeic acid, possessing strong antioxidant, radical-scavenging, and antibacterial activities. The majority of the phenolic acids in Sage species are derivatives of caffeic acid which is the building block of a variety of plant metabolites. Caffeic acid plays a central role in the biochemistry of the Lamiaceae plants, and occurs mainly in a dimer form as rosmarinic acid. Carnosic acid and rosmarinic acid, which are present at high concentrations in the extract of Sage plants, have shown strong antioxidant properties. Ursolic acid, also a component of sage, has strong anti-inflammatory properties, and in sage preparations, it is considered as a quality control measurement for the anti-inflammatory effects of different

This indicates that the metabolism of proteins was apparently affected by Ch.t extract. The improvement on the levels of protein and albumin in the diabetic treated groups show that Ch.t extract have significant effect in glucose and protein level because insulin inhibit gluconeogenesis from protein [ ] or could be due to improvement in renal function. This affirmative agrees with the fact that the weight of skeletal muscles was significantly increase in diabetic rats treated with Ch.t extract. The decrease in albumin level documented for diabetic rats may be due to liver massive necrosis, deterioration of liver function, hepatic resistance to insulin and glycogen impairment of oxidative phosphorylation[ ].Under the same experimental conditions serum globulin level revealed an appreciable decrease[ ]. The renal pathogenesis is related to duration of diabetes, the most devastating complication with diabetes is nephropathy[

Cancer is one of the leading causes of death. What if there was a safe, natural herb that could work for nearly every type of cancer?

may help kill certain cancer cells and reduce the size of others. Evidence from one cell culture study

The extracts and polyphenols suppressed cell proliferation, promoted apoptosis, modulated signaling transduction, inhibited cell invasion, and prevented angiogenesis and metastasis in animal models related to multiple types of cancer such as liver, bladder, prostate, intestine, colon, pancreas, and mammary gland in more than one hundred publications (Yang & Wang, 2010; de Moura et al., 2013). Green tea has been studied expansively for its cancer prevention effects which are believed to be associated with green tea polyphenols known as "catechins (-)-epigallocatchin-3gallate (EGCG), (-)-epigallocatechin (EGC), (-)-epicatechin-3-gallate (ECG), and (-)-epigallocatechin (EC)...they each have a level of antioxidants and are strong metal ion chelators, which prevent the formation of reactive oxygen species (ROS)" (Yang & Wang, 2010, p. 931; Ziech et al., 2012). Further research has revealed that high concentration levels are necessary to accomplish this, and adding other agents such as Atrovastatin, a drug used to lower cholesterol, increase success (Yang & Wang, 2010). EGCG has demonstrated the most success because it "serves an antioxidant, or pro-oxidant, and

Main compounds of the enzymatic antioxidant system are three, namely, SOD, CAT and tT which have an important role in detoxifying of H2O2 and superoxide anion in cells. Ample of hepatotoxic drugs induces the liver damage by lipid peroxidation indirectly or directly. The proxy radicals are main factors that mediate lipid peroxidation leading to liver injury and kidney damage(41). MDA as a main reactive aldehyde appears during polyunsaturated fatty acid peroxidation in the biological

Mulberry and blueberry are examples of the berries species that contain high antioxidants and low in calories. These berries may contribute in minimizing and preventing the risk of diabetes due to the presence of high amounts of phenolic compound and flavonoids such as anthocyanin. It may exhibit neuroprotective and anticancer activity (Wang Y, Xiang L, Wang C, Tang C, He X, 2013). The reaction of the antioxidants in berries related to the reduction of oxidative stress and inhibition of macromolecular oxidation in fruits that high in phenolic compound (Larson, 1988). The anthocyanin content also have other health-related function such as anticancer, antiaging and antiobesity. However, the research regarding these functions still in progress and some of the research still needs a further improvement. The rich content of poplyphenol in berries helps in reducing the oxidation and producing the insulin to reduce the blood glucose

Scientists at the University of Arizona Cancer Center have found that sulforaphane, a compound in broccoli could help prevent skin disease. The scientists have been trying to research methods to prevent skin cancer that are affordable and easy for the public to use. One of the scientists, Dr. Dickinson, has researched the benefits of broccoli on skin cancer since 2005 and has found that sulforaphane is very effective at inhibiting the cancer causing pathways of skin cancer. The scientists are conducting an experiment with a tropical broccoli sprout solution on a group of people, to see if the solution works when the skin is exposed to artificial light. Sulforaphane is also very effective at preventing sunburns so scientists are hoping to

Licorice root is used worldwide as a natural sweetener, as well as a flavoring agent. The main composition of plant Flavonoids and Isoflavonoids act as inhibition platelet aggregation, and anticancer, antioxidant (20). Aly et al.,2005(21) indicate that liqurice have potent anti-inflammatory reduction edema about 78.3 while diclofen about 73.9% also have anti-ulcerogenic activity associated with a reduced acid output and an increased mucin secretion, an increase in prostaglandin E2 release and a decrease in leukotrienes (22). Many volatile oil and vitamins such as B1,B2,B3,B6,C,E, Biotin, Foli acid, Pantothenic acid act as expectorant, laxative, liquiritin act as antitussive (23). Also contain Coumarins Herniarin and umbelliferone (24).moreover plant used for treatment of asthma , chronic fatigue, hormonal disturbance , antiviral, antibacterial , hepatoprotective, anti-oxidant , antiulcer, ant mutagenic, Hypothermic antioxidant, anti-inflammatory, relieve pain , expectorant, hypoglycemia,

Panax notoginseng, a root of Panax notoginseng (Burk.) F.H. Chen, has been traditionally used as either functional food or herbal medicine. Previous studies show that Panax notoginseng is used in cardiovascular disease, cerebrovascular diseases, diabetes, pains, and bleeding (Ng, 2006; Wang et al., 2009; Yang et al., 2014). In cancer prevent and therapy research, Panax notoginseng is beneficial to the prevention and treatment on colon, liver and breast cancer (Chen et al., 2006; Wang et al., 2007; Toh et al., 2011; He et al., 2012; Wang et al., 2009; Wang et al., 2012 ). Although, Chen et al. (2006) have been show that Panax notoginseng can suppress liver metastasis of C57BL/6 mice. And, a ginsenoside from Panax notoginseng, 20(S)-25-methoxyldammarane-3b,

In conclusion, current study provides evidence that the therapeutic efficacy of cisplatin alone or in combination with licorice is less effective in comparison with that of licorice alone in case of the treatment of HCC in rats. cisplatin has been one of the more efficient anticancer chemotherapeutic agents because it effect in multiple intracellular sites in order to induce death in tumor cells. Nevertheless in order to increase the efficiency of cisplatin, other drugs are used in combination. More research is necessary in order to improve anticancer treatments and to decrease toxic effects. Our results demonstrate that the aqueous extract of licorice showed a significant effect in amiolerating liver functions as well as estoring hepatic tissue in acute liver diseases when the extract was administered in single dose per day of 2gm/kg body weight. The potency of the different treatment regimens in HCC therapy is arranged in the following order: licorice alone > licorice plus cisplatin > cisplatin alone.

Sulforaphane in broccoli compound reduced the number of breast cancer cells stem (causing the cancer will spread and repetition) in rats, according to research from the University of Michigan. Eating Broccoli may not deliver sulforaphane enough to achieve the same purpose, but for most you can eat your broccoli raw or briefly steamed or stir fry green

DMBA is an effective chemical used to induce breast tumorigenesis in rats. In this study, DMBA treatment led to the development of tumors by rats as revealed by tumorigenesis analyses and the histopathological examination. Treatment with lycopene reversed the pathological changes showing the efficiency of lycopene in breast tumor treatment. This result was in accordance with previous studies where lycopene alone or in combination with other products was proven to have anti-tumor activity.

The roots extract was used to see if it would slow down the growth of cancerous cells or not. The cancer cell lines used was A549 cell also known as lung cells, and BT549- breast cancer. Components used in this experiment include alamar blue, media DMEM, Tamox, DMSO, centrifuge tubes, pipets, and micropipets. Alamar blue also known as Resazurin is a growth indicator used to detect metabolic activity. An oxidation- reduction indicator to show color changes resulting from cell growth. In this experiment if the solution turns red, it indicated that cancer cell lines were growing. Media DMEM was used as a PH indicator, also as a nutrient for the cell. The PH was to be a neutral of 7.0. Tamox killed the cells and was used as the positive control. DMSO was the negative control. The purpose of this experiment was to identify if the compounds were good candidates towards the cure for cancer. Observation was made to see if the cells would die through

ECGC is the most potent of flavonoids, and it helps fight against free radicals. Which is an atom and when their paired with unpaired valance electrons it makes the free radical extremely radioactive towards other things in the body which can lead to cancer. Green teas antioxidants interfere with the development of colorectal cancers, the antioxidants found in Chamomile tea also stunt the growth of cancer cells. White tea has the more dominant anticancer properties.