preview

Benzodiazepine Vs Pharmacotherapy

Decent Essays

Most of the patients exhibit improvement in the symptoms of panic disorder after receiving the treatments, the two most effective treatments are cognitive behavioral therapy and pharmacotherapy.
Pharmacotherapy:
The selective serotonin reuptake inhibitor and the tricyclic antidepressant have shown superiority over the benzodiazepines, monoamine-oxidase inhibitor in term of effectiveness and tolerance.
The commonly used drugs are:
1) SSRI group: PAROXETINE, FLUOXETINE, SERTRALINE,FLUVOXAMINE,CITALOPRAM.
2) Tricyclic antidepressant: CLOMIPRAMINE, IMIPRAMINE, DESIPRAMINE.
3) Benzodiazepines group: ALPRAZOLAM, CLONAZEPAM, DIAZEPAM, LORAZEPAM.
4) Mao-i: PHENELZINE, TRANYLCYPROMINE, REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE, MOCLOBEMIDE, BROFAROMINE. …show more content…

While the benzodiazepines are administered the serotonergic drug can titrated to reach the therapeutic dose, and then four to twelve weeks after benzodiazepines can be tapered slowly. (13)
The role of atypical antipsychotic and antidepressant in treating panic disorder: Atypical antipsychotic:
Many studies proved the efficacy and tolerability of the atypical antipsychotics on patients that diagnosed with panic, one method was constructed by searching for relevant published articles that investigate the antipsychotic effect on panic patients. After removing duplicated and the case report studies they obtained seven studies, 4 out of 7 were open label studies, 2 out of 7 were randomized controlled trials for PD comorbid with major depressive disorder and one randomized control trial for PD comorbid with bipolar disorder.
The most common drugs that have been used in these studies were the Risperidone, Aripiprazole, olanzapine and Quetiapine.
The results shows that 6 out of the 7 studies have proved the efficacy of these drugs on panic disorder patients alone or with comorbidity, being introduced either as a mono therapy agent or an augmenting

Get Access