Best Quality Evidences Based Practice to Evaluate the Effectiveness of Using ARBs for Diabetes Type 2

1092 Words Feb 26th, 2018 4 Pages
Four RCTs studies were reviewed in this literature. All the selected RCTs were at a high quality level of methodology according to the appraisal tools of SIGN for RCTs. Adrienne et al (2003) , Raymond et al (2006) and Adrienne et al (2006) were scored 1++, and Adnan et al (2009) was graded by +1.

The findings of the four RCTs Adrienne et al (2003), Adrienne et al (2006), Raymond et al (2006) and Adnan et al (2009) reported the significant reduction of microalbuminuria in diabetes type 2 with normotensive with the use of ARBs compared to the control group (see appendix( 4) for summary findings for the studies).

Moreover, the Raymond et al (2006) study included additional drug to the ARBs during the study in order to control blood pressure in the intervention group. The studies concentrated on the effect of ARBs on reducing the level of microalbuminuria either as a primary outcome or secondary outcome. That highlights the important role of ABR in reduction of miceoalbuminuria.

However, there were limitations and strengths in those RCTs that influence the results. For instance:
Sample size: The numbers of participants in these studies were small comparing to DMT2 patients worldwide. The highest study…
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