As the cells change, it begins to divide rapidly causing a tumor to form. The term “breast cancer” refers to a malignant tumor that has developed from cells in the breast. Breast cancer can begin in different areas of the breast, or in some cases, the tissues in between. There are many different types of breast cancer, including non-invasive, invasive, recurrent, metastatic breast cancer, as well as the intrinsic or molecular subtypes of breast cancer. Human epidermal growth factor receptor 2 (HER2) is overexpressed in around 20-30% of breast cancer tumors. It is associated with a more aggressive disease, higher recurrence rate, and increased mortality.
Genes contain the recipe for the various proteins a cell needs to stay healthy and
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But there are medicines specifically for HER2-positive breast cancer.
How your results appear in the report will depend on what test you have. There are four test for HER2. ImmunoHistoChemistry (IHC test) finds out if there is too much HER2 protein in the cancer cells. The results of the IHC test can be 0 (negative), 1+ (also negative), 2+ (borderline), or 3+ (positive- HER2 protein overexpression). The Fluorescence in Situ Hybridization (FISH) test finds out if there are too many copies of the HER2 gene in the cancer cells. The results of the FISH test can be positive (HER2 gene amplification) or negative (no HER2 gene amplification). The Subtraction Probe Technology Chromogenic In Situ Hybridization (SPoT-Light HER2 CISH) test finds out if there are too many copies of the HER2 gene in the cancer cells. The results of the SPoT-Light test can be positive (HER2 gene amplification or negative (no HER2 gene amplification). The Inform Dual In Situ Hybridization (Inform HER2 Dual ISH) test finds out if there are too many copies of the HER2 gene in the cancer cells. The results of the inform HER2 Dual ISH test can be positive (HER2 gene amplification) or negative (no HER2 gene amplification). It is important to know which HER2 status test you had. Generally, only cancer that test IHC 3+, FISH positive, SPoT-Light HER CISH positive, or Inform HER2 Dual ISH positive respond to the medicines that target HER2-positive breast cancers. An IHC 2+ test
Triple-negative breast cancers constitute about 15% of all cases, but despite their higher response to
Breast cancer in males is quite common, yet still many people are unaware of this disease. Often, it can go undiagnosed until the cancer is in the fourth stage. Every year over 2,000 men will be diagnosed, but only 54% will survive. Cancer in men is often overlooked as it is almost 100 times less common in men than women. During a man’s entire lifespan, the risk of having a diagnosis is about one in one-thousand. The most common symptom of this devastating disease are a lump or some swelling. This can be around the breast tissue, nipple, under the arm, or even on the neck. Male breast cancer can spread to the lymph nodes underneath the arm or above the collarbone even before it is noticed on the breast. The lumps are usually painless but
Over the past decade breast cancer has become one of the most predominant diseases in the United States. Breast cancer starts out as a malignant tumor in the tissues of the breast which is formed from the uncontrolled growth of abnormal breast cells. Breast cancer is the most common cancer in women, but it can also appear in men. (Stephan, 2010)
There are no symptoms at the early stages of breast cancer which makes early detection even more difficult. When tumors become large there is an obvious breast mass which is mostly not painful. Symptoms of breast cancer include breast thickening, skin irritation, tenderness, swelling, breast scales, distortion, redness tenderness, nipple retraction and ulceration, There may also be abnormal discharge.
Breast Cancer is a type of cancer where in the breast cells growth are uncontrolled. To enhance our understanding of breast cancer, knowing how any cancer can develop is crucial. Cancer develops as a result of the alteration of the genes, or abnormal changes in the genes accountable for managing the growth of the cells and maintaining their health. In each nucleus, the genes operates as the “control room.” The cells in our bodies replace themselves through a process called cell growth in which the
An effective breast cancer treatment in some women can be traced to the root of the disease. Some of the most aggressive form of breast cancers are caused by a transmembrane receptor protein known as Human Epidermal Growth Factor Receptor 2 (HER2) which is a member of the HER family of receptor tyrosine kinase. Approximately 20,000 HER2 receptor are normally expressed on surface of healthy breast cell however, in about 25% of breast cancer cells the HER2 protein is overexpressed resulting in tumour cells with as many as over 2 million receptors present on their surface. This cancer is known as HER2 positive (HER2+). The effect of HER2 overexpression is an increase in receptor mediated intracellular signalling causing the cell
Breast cancer is a disease in which certain cells in the breast become abnormal and multiply uncontrollably to form a tumor. Breast cancer is the second most commonly diagnosed cancer in women. (Only skin cancer is more common.) About one in eight women in the United States will develop invasive breast cancer in her lifetime. Researchers estimate that more than 230,000 new cases of invasive breast cancer will be diagnosed in U.S. women in 2015. Cancers occur when a buildup of mutations in critical genes—those that control cell growth and division or repair damaged DNA—allow cells to grow and divide uncontrollably to form a tumor. Breast cancer can be caused by inherited genetic factors. These genetic
Breast cancer constitutes the second most prevalent cancer most common among women of the world with an estimated 1.62 million reported cases in 2012 which constitutes 25% of all cancer cases and ranks fifth among mortality due to cancer (Ferlay et al., 2015). In the United States, according to American Cancer Society an
During the course of breast cancer treatments, most patients will undergo radiotherapy. Many women who undergo radiation therapy may develop a skin reaction in the area receiving radiation. The reaction is like sunburn, the skin turns pink or red and there also maybe peeling. The effect of deodorant on breast cancer therapy has generated significant interest in Oncology and in the scientific community. While the exact mechanism linking deodorant use to skin toxicity is yet to be determined there are two hypothesis. One hypothesis involves deodorant acting to increase the concentration of the radiation applied to skin and the other focuses on an adverse reaction between the metallic components and the external radiotherapy. Hardefeldt, Edirimanne,
Cancers are a large family of disease that involve abnormal cell growth which can then spread to other parts of the body.This year about 564,800 Americans are expected to die of cancer, more than 1,500 people a day. Cancer may be identified with many kind of symptoms depending on where in the body is the cancer located, how big is the cancerous tumor and how much is affects the surrounding organs and tissues.
Breast cancer is the most common type of cancer in women, it accounts for one of every three diagnoses in the United States. Breast cancers are malignancies, life threatening tumors that develops in one or both breasts.
Today in the world there are many different types of reproductive cancers. A reproductive cancer I’m going to be writing about is Breast cancer. Yes, its Breast Cancer. According to American Cancer Society (2017) Breast cancer is “Breast cancer starts when cells in the breast begin to grow out of control. These cells usually form a tumor that can often be seen on an x-ray or felt as a lump. The tumor is malignant (cancer) if the cells can grow into (invade)surrounding tissues or spread (metastasize) to distant areas of the body. Breast cancer occurs almost entirely in women, but men can get cancer too (pg.1). Although Breast cancer first start in the breast, it can also start from other places surrounding that tissue or area.
There are four stages of breast cancer. The Stage 0 is noninvasive breast cancer, that is, carcinoma in situ with no affected lymph nodes or metastasis. Stage zero is the most favorable. Now Stage 1 breast cancer is less than two centimeters in greatest dimension and is only in the breasts. In Stage 2, the cancer is no larger than two centimeters but it has spread to the lymph nodes under the arm. The
Breast cancer is the second leading cancer killer among women, after lung cancer (Breast Cancer , 2014). Cancer is a word that puts fear in many people, especially if they have family members who have either died or survived the disease. No one wants to hear that he or she has been diagnosed with any disease, especially cancer. Many women do not take breast cancer serious until they are diagnosed. Sadly, once diagnosed with this epidemic, a person’s life is altered forever. Breast cancer does not discriminate and can happen to anyone at any age. To prevent this disease, one must take the necessary precautions to lower the risk factors. In fact, there are several local and national events to remind people of breast cancer’s existence. Many
Breast Cancer is a cancer that forms in tissues of the breast, usually the ducts (tubes that carry milk to the nipple) and lobules (glands that make milk). It occurs in both men and women, although male breast cancer is rare. Anyone women could be at risk for breast cancer but, there are factors that make some women more susceptible to breast cancer than others. A risk factor is anything that affects your chances of getting a particular disease. Some can be controlled and some can’t. The ones you can control are genetics or family history, and environmental exposures or behaviors that might have happened in the past. The current and future behaviors can be controlled like exercise and a good diet. You also need to watch