Herceptin Essay

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Introduction
An effective breast cancer treatment in some women can be traced to the root of the disease. Some of the most aggressive form of breast cancers are caused by a transmembrane receptor protein known as Human Epidermal Growth Factor Receptor 2 (HER2) which is a member of the HER family of receptor tyrosine kinase. Approximately 20,000 HER2 receptor are normally expressed on surface of healthy breast cell however, in about 25% of breast cancer cells the HER2 protein is overexpressed resulting in tumour cells with as many as over 2 million receptors present on their surface. This cancer is known as HER2 positive (HER2+). The effect of HER2 overexpression is an increase in receptor mediated intracellular signalling causing the cell
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The most common adverse reactions are fever, nausea, vomiting etc
The aim of this report is to provide primary evidence which supports and explains the reasons why Herceptin is used in the treatment of HER2+ cancers.

The place in therapy of Herceptin
Adjuvant Use
Herceptin can be used as an adjuvant treatment for breast cancer. [7] The inclusion criteria for adjuvant Herceptin therapy includes HER2+ breast cancer, nodal positive tumour, patients who have received approved neoadjuvant or adjuvant chemotherapy regimen and a normal cardiac function. [8][9] Exclusion criteria includes patients with a clinically significant coronary heart disease, patients requiring continuous oxygen etc. In adjuvant breast cancer therapy, Herceptin can be used in addition to other chemotherapy drugs like doxorubicin, cyclophosphamide and either docetaxel or paclitaxel in a treatment regimen known as AC-TH. It can also be used in another treatment regimen known as TCH which includes docetaxel and cyclophosphamide. Herceptin can also be used as monotherapy treatment following a chemotherapy regimen. [8] Monotherapy Herceptin can only be given as a three-weekly schedule at a loading dose of 8mg/kg and a

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