Human Cardiac Fibroblasts (HCFs) are the most prevalent cell type in the heart, comprising 60-70% of all cells. They play a central role in the maintenance of the ECM in the normal heart and the synthesis of growth factors and cytokines. Under pathological conditions, cardiac fibroblasts are involved in scar formation following myocardial infarction, cardiac fibrosis, and cardiac hypertrophy.
As mentioned previously, cardiac muscle includes involuntary striated muscle of the heart. Cardiomyocytes are the muscle cells that contract to propel blood through the heart chambers, lungs, and circulatory vessels.
2.1.5 BONE CELLS: OSTEOBLASTS, OSTEOCLASTS, AND OSTEOCYTES
Bone is a very dense, specialized form of connective tissue. Bone matrix is comprised
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Myeloid cells include monocytes and macrophages, neutrophils, basophils, eosinophils, erythrocytes or red blood cells, megakaryocytes or platelets, and dendritic cells, while lymphoid cells include T cells, B cells, and natural killer cells. HSCs are primarily found in the bone marrow niche, but they can be recruited into the circulation by chemokines and therefore are also present in peripheral blood. As with other stem cells, they are self-renewing and multipotent. Unlike MSCs, however, HSCs are non-adherent cells, meaning that they are cultured while suspended in liquid media and do not adhere to tissue culture-treated plastic. Cell surface markers for HSCs include CD45, CD133, and CD105, and negative for standard lineage markers of HSC differentiation. These surface markers are used for identification of HSCs from other cell types; however, due to interspecies variation, common HSC markers also differ slightly across humans and mice, which are commonly used experimentally. For example, human HSCs are positive for CD34, CD59, CD90/Thy1 markers, while in mice, HSCs are positive for CD38, Sca-1, and c-Kit …show more content…
The immune system includes innate and adaptive immune responses. The innate immune system acts as the first line of defense to rapidly and nonspecifically respond to foreign pathogens. The adaptive or acquired immune system, however, responds to pathogens to create a long-term immunological memory. As a result, the adaptive immune system can initiate a heightened response to subsequent exposures to the same pathogen and provide a protective immunity. Leukocytes can be classified as neutrophils, eosinophils, basophils and mast cells, monocytes/macrophages, and
The immune system is made up of several types of cells that work together to fight infections. Lymph cells (called lymphocytes) are the main type of cell in the adaptive immune system. There are 2 types of lymph cells: T cells and B cells. When B cells respond to an infection, they change into plasma cells. The plasma cells are found mainly in the bone marrow—the soft, inner part of some bones. The plasma cells
Hypertrophic cardiomyopathy is an inherited disease that affects the cardiac muscle of the heart, causing the walls of the heart to thicken and become stiff. [1] On a cellular level, the sarcomere
The cardiac muscles are the muscle of the heart itself. The cardiac muscle is the tissue that makes
Innate Immune System – Nonspecific and abrupt first response; comprised of epithelial surfaces (physical barriers), neutrophils, and macrophages.
The immune system is made up of trillions of specialised cells (white blood cells) that detect and destroy pathogens or their toxins. Some white blood cells, which are
The human immune system creates a series of responses in the body to defend the body. If a foreign organism, such as a virus or a cold invades your body, it recognizes these foreign organisms, and, in turn, attacks them to get rid of them. One can think of the immune system as an army of many cells which have set up their own bastion in the human body. They have only one job: To defend. The immune system’s cells are various kinds of white blood cells. The human body typically creates about 1000 million white blood cells on a daily basis. A group of these cells, macrophages, establish a patrol of sorts throughout the body killing germs as soon as they enter the body. However, sometimes an infection can cause the macrophages to succumb to it. The body begins to fight back with stronger T- and B-cells.
Hematopoietic stem cells are unspecialized cells that can develop into all types of blood cells, such as white blood cells, red blood cells, and platelets. These cells can be found in the peripheral blood, unbelicalcord and the bone marrow. There are four different types of hematopoietic stem cell (HSC) transplants. They are autologous transplant, allogeneic transplant, myeloablative transplant, non-myeloablative transplant.
Humans such as us alike cannot live in a world without a highly effective defense system that helps us to resist against infections and toxins caused by microorganisms. The immune system is a complex network of consorting cells, tissues and organs that defend the body from pathogens and other harmful substances. This essential complex consists of two subsections : the innate immune system and the adaptive immune system.
Adult stem cells are found in abundance all over the body in specific organs and tissues such as the brain, peripheral blood and liver. The region in which they are found is key to their function; for example, it is easier to stimulate cardiomyocyte stem cells to differentiate into cardiac muscle than it is to use bone marrow stem cells for the same purpose. Embryonic stem cells are cells which are grown from other cells found in the embryo when they are just a few days old.Embryonic steam cells are grown in laboratories from a group a cells found in the embryo very early on. Human embryonic steam cells are taken from embryos that are 5 to 6 days old.Embryonic stem cells are extracted from embryos and often these steam cells are taken from embryos that develop from eggs that have been fertilized in vitro. In vitro fertilization clinics use donated eggs for the purpose of research.Given that researchers may be able to study all cell types via embryonic stem cells, they have the potential to make breakthroughs in any disease. Similar to other cells, embryonic steam cells have the ability self-renew and differentiate. However, embryonic steam tells are differ from other cells, they have the ability to form into various types of cells in the body.Their versatility allows embryonic steam cells to repair several diseased
Hypertrophic Cardiomyopathy was discovered by Donald Teare, a pathologist, about five decades ago (1958). Over the last 50
Myocarditis is the term used when inflammation is present in the middle layer of the heart wall. The most common cause is a viral infection related to an upper respiratory infection. It can also be the result of exposure to environmental toxins, autoimmune disorders, and harmful reactions to medications. Although the chances are relatively low (about ten to fifteen percent), myocarditis has been known to be a recurrent condition, and there is no way to prevent this from happening.
The body has two immune systems: the innate immune system and the adaptive immune system.
The immune system is comprised of two responses: the adaptive immune response and the innate immune response. The first line of defence against invading organisms is classified as the innate immune response and the second line of defence and protection against re- exposure to the same pathogen is known as the adaptive immune response.
This table shows the similarities and differences between the cardiac and skeletal muscle. One of the main similarities is the fact both muscles are categorized as striated muscles. Striations are the main key to identifying the skeletal and cardiac muscle. The striated muscles are attached to the bone of the cells in which they produce all the movement in the body. Another similarity is that they can be electrically conducted because they both contain t-tubules. The t-tubules are the plasma membrane of both muscles. They allow depolarization of the membranes which then penetrate into the cell.
Our immune system is made up of two parts that work together to keep us healthy. The first part is called the innate immune system, it is made up mostly of ‘scavenger’ and ‘killer’ cells that fight off bacterial infections and give the body a general defense against harmful substances. The second part of the immune system is called the adaptive immune system. This part