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Cardiac Fibroblasts Research Paper

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Human Cardiac Fibroblasts (HCFs) are the most prevalent cell type in the heart, comprising 60-70% of all cells. They play a central role in the maintenance of the ECM in the normal heart and the synthesis of growth factors and cytokines. Under pathological conditions, cardiac fibroblasts are involved in scar formation following myocardial infarction, cardiac fibrosis, and cardiac hypertrophy.
As mentioned previously, cardiac muscle includes involuntary striated muscle of the heart. Cardiomyocytes are the muscle cells that contract to propel blood through the heart chambers, lungs, and circulatory vessels.
2.1.5 BONE CELLS: OSTEOBLASTS, OSTEOCLASTS, AND OSTEOCYTES
Bone is a very dense, specialized form of connective tissue. Bone matrix is comprised …show more content…

Myeloid cells include monocytes and macrophages, neutrophils, basophils, eosinophils, erythrocytes or red blood cells, megakaryocytes or platelets, and dendritic cells, while lymphoid cells include T cells, B cells, and natural killer cells. HSCs are primarily found in the bone marrow niche, but they can be recruited into the circulation by chemokines and therefore are also present in peripheral blood. As with other stem cells, they are self-renewing and multipotent. Unlike MSCs, however, HSCs are non-adherent cells, meaning that they are cultured while suspended in liquid media and do not adhere to tissue culture-treated plastic. Cell surface markers for HSCs include CD45, CD133, and CD105, and negative for standard lineage markers of HSC differentiation. These surface markers are used for identification of HSCs from other cell types; however, due to interspecies variation, common HSC markers also differ slightly across humans and mice, which are commonly used experimentally. For example, human HSCs are positive for CD34, CD59, CD90/Thy1 markers, while in mice, HSCs are positive for CD38, Sca-1, and c-Kit …show more content…

The immune system includes innate and adaptive immune responses. The innate immune system acts as the first line of defense to rapidly and nonspecifically respond to foreign pathogens. The adaptive or acquired immune system, however, responds to pathogens to create a long-term immunological memory. As a result, the adaptive immune system can initiate a heightened response to subsequent exposures to the same pathogen and provide a protective immunity. Leukocytes can be classified as neutrophils, eosinophils, basophils and mast cells, monocytes/macrophages, and

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