An unusual case of Euphorbia.tirucalli sap poisoning
ABSTRACT: Euphorbia .tirucalli sap is extremely irritating to the skin and mucosa .on accidental exposure it causes vesication in the skin and inflammation involving eye sight in the eyes. On oral ingestion, it acts as an irritant, causing vomiting, diarrhea, convulsions and coma. It is used as a local irritant application for procuring criminal abortion, but rarely for homicidal and suicidal purposes.
We came across a case of oral consumption of sap of Euphorbia .tirucalli for suicidal purpose. Patient responded to supportive treatment and recovered over a week without any sequalae. This case highlights the fact that, even though Euphorbia .tirucalli sap poisoning is very rare, these patients
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Euphorbia tirucalli (E.tirucalli) is also known as Indian Tree Sponge, Milk Hedge, Fire stick Plant, Pencil tree (2).
Euphorbium is an acrid milky juice exuded from stems of various euphorbius plants belonging to Euphorbiaceae. The toxic part is latex. Toxins differ based on species (1).The latex of E.trucalli contains poly cyclic diterpene esters (3).
The latex on oral ingestion acts as an irritant causing vomiting, diarrhea, burning sensation in the abdomen, convulsion and coma. Irritant toxins indirectly stimulate contraction of the gastrointestinal smooth muscles by mechanical irritation. Skin exposure produces an irritant dermatitis and ocular exposure causes an irritant keratoconjuctivitis. Our patient had gastro intestinal symptoms (vomiting, diarrhoea and abdominal pain).Management includes symptomatic and supportive care (1). In Europe veterinary practitioner used this sap as vesicant. One to four drops of the juice is used as a purge. Twig of the plant is used as a local irritant for procuring criminal abortion
Use the root in a tea to enhance psychic powers. Used in Samhain rituals. Sleep, protection, healing. Bury in northwest corner of yard to bring favorable winds. Use in sachets and charms to make wishes come true.A very nutritious and universally beneficial herb. Use in dream pillows and sachets, the leaves and flowers can be used in tea for healing.
Despite the widespread popularity amongst First Nations people, however, and while “at least some of the traditional remedies involving devil’s-club may have a sound biochemical basis (Turner, 1982, p. 17)”, it hasn’t been widely used at this stage in the modern commercial market. There is ongoing research to determine its potential benefit for commercial pharmacological use, and there is some concern for what the implications of this could be for this slow-growing, sensitive shrub.
Ergot, the toxic fungus found on rye, is mostly found during the spring and summer months with humid climates (Clues and Evidence). When reproducing, the contaminated grain releases a yellow thick, sticky substance which contains the fungus that spreads the poison throughout the crop. Once the grain is infected, it’s seeds contain lysergic acid which is what the hallucinogen LSD is created from (Clues and Evidence). Some side effects of ingesting Ergot are: “... strange mental aberrations, hallucinations, a feeling of burning skin or insects crawling under the skin. Women frequently miscarried, and fertility was generally reduced during outbreaks… many victims lost hands and feet” (Schumann). Victims of the lethal infection also experienced convulsions, paralysis, tremors and acting disturbed or insane(Schumann).
from twigs and herbs and used to purify, cleanse, and protect. The Besom is traditionally crafted
This lecture covered stimulants and hallucinogens, such as the morning glory which has alkaloids similar to LSD, but has about 10th the potency of LSD. Typically the seeds are coated with an herbicide so users must be cautious when using morning glory. Mescaline is derived from the peyote cactus, and is not legal in America, but is permitted in some states for the use among Native American religious ceremonies. Plants with hallucinogenic properties such as belladonna, mandrake, henbane, and Datura have all been around for centuries, and have serve various purposes other than just the psychoactive effects. Henbane has been used as part of a cure for alcoholism, as well as being used to poison hamlets father. The ancient Chinese used Datura to
Many of these deadly poisonous plants are the stuff of folklore and have alarming names such as Devil’s helmet,deadly nightshade, the little apple of death and the suicide tree. Whilst these would be enough to put any sane person off eating them I suppose it only helps if you know the name!
Children are less likely to experience aslow heart rate, sweating, muscle tremors or tear production, but are more likely toexperience lethargy, muscle weakness, constricted pupils, excessive production of saliva,seizures, or coma. Other, more severe conditions such as intermediate syndrome andOrganophosphate-Induce Delayed Neuropathy (OPIDN) can occur at very high exposurelevels (Gervais et.al, pp. 3-4).4. Dose-Response AssessmentIn the laboratory, rats and rabbits were exposed to varying levels of Malathion todetermine its effects. Death occurred in rats at levels 1,000-12,500 mg per kilogram ofbody weight when ingested. When placed on the skin, death occurred at 2000 mg/kg orgreater. When inhaled, death occurred at greater than 5.2 mg/L. As these figures arebased on body weight and lung capacity, death in humans would require significantlyhigher exposures, which is why the EPA considers Malathion to be low or very low intoxicity (Gervais et.al, pp. 2-3).Five humans ingested Malathion (voluntarily) at 0.23mg/kg/day for 47 days, andshowed no notable reduction in the activity of AChE. When the dose was increased to0.34mg/kg/day for 56 days, all five volunteers showed signs of reduced activity of AChEtwo weeks after the experiment began. The highest amount of AChE reduction was 25%,which was recorded up to 3 weeks after the end of the experiment. The inhalation trialsincluded doses of 5.3, 21.0, and 85.0 mg/m3 for one hour, twice a day for 42 consecutivedays. The volunteers reported eye and nose irritation for 5-10 minutes following thebeginning of exposure, but no reduction in AChE activity was found (Gervais et.al, p.5).Fish and rats were
to the eyes and lungs, so it is effective in low doses as an irritant (Murphy-Lavoie & Martinez,
The plant species named Veratrum californicum caused an epidemic of sheep congenital deformities raised the possibility that jervine alkaloids are also potent teratogens. Extensive studies confirmed
The death cap mushroom, Amanita phalloides, is responsible for about 90 percent of mushroom ingestion fatalities. While initially people may feel fine after eating the mushrooms, within 12-24 hours they will feel gastrointestinal distress, and then within two days start to show decline in liver function as evidenced by deterioration of liver enzyme tests and jaundice. Acute liver failure follows and renal function also deteriorates. Within one to three weeks, patients die from multiple organ failure, disseminated intravascular coagulation, mesenteric thrombosis, and convulsions. There is no antidote. Treatment consists of detoxification, chemotherapies, and liver transplant. (Santi, Maggioli, Mastroroberto,Tufoni, Napoli,Caraceni 2012)
The cons for the change to latex free would be cost, education and time taking to convert the supplies to latex free. The pros outweigh this, an unintended exposure to a patient with a latex allergy could be deadly. Natural rubber latex is produced from a tree which has 13 proteins will allergenic properties and is present in 40,000 products of daily life(Grossman & Porth, 2014). Genetic polymorphism of 30 genes and 15 different chromosomes have been identified as participants in the allergy (Grossman & Porth, 2014). Even if one of the components are present in latex manufacturing, it may be capable of producing a reaction. People who receive repeated exposure to latex can develop allergies, specifically health care workers, chronically ill patients with rectal and urinary issues requiring procedures. Additional items that share proteins with latex are tree pollen, avocados, bananas, celery and pear cross-sensitivity (Grossman & Porth, 2014).
The experiments in the 1800s revealed the mystery of the Calabar beans and its physiochemical properties. In the 1855, Robert Christison, a Scottish toxicologist and physician experimented Calabar bean on himself. When he realized he poisoned himself, he drank soapy water to make himself vomit. In the 1862 Thomas Fraser found the power of physostigmine contracting the pupils of the eyes. In the 1864, the alkaloid was crytallized by Jobst and Hesse, which they called “Physostigmine”. In the 1865, Vee and Leven independently isolated an alkaloid from Calabar beans. They called it eserine. In the 1870, the Calabar beans were used successfully to treat glaucoma. In the 1973, Barthlow discovered the antagonism between atropine and physostigmine. In the 1935, Percy Julian accomplished the first total synthesis of the physostigmine. In the 1936, Ed Alburquerque discovered that physostigmine protects against nerve gases.
My first impression of this passage was that it seemed comedic. Not to the characters involved, but to the readers looking in. The euphio has turned off and there are different reactions to it. There’s Lew wondering why no one’s cheering. Marion is crying over Fred who had been hurt since the Euphio was first turned on.
2. Nerium Oleander is an evergreen shrub that is a potentially lethal plant due to its contents of cardiac glycosides. Over the years, this plant has been used as a natural remedy to treat indigestion, malaria, and leprosy. Recent studies are being conducted to determine its potential as a chemotherapeutic agent. This cardiac glycoside works by inhibiting the Na/K+ ATPase enzyme, which results in severe life threatening hyperkalemia. Some of the initial clinical signs include: nausea, vomiting, diarrhea, gastrointestinal discomfort, and hypersalivation. Cardiac symptoms include sinus
According to the U.S. Food & Drug Administration, there are four categories of mushroom toxins, Protoplasmic poisons, which destroys cells and causes organ failure and death, neurotoxins, which cause neurological symptoms such as sweating, coma, convulsions and hallucinations, gastrointestinal irritants, which cause nausea, vomiting, diarrhea, abdominal cramps, and disulfiram-like toxins, which are normally not toxic and there are no symptoms unless alcohol is consumed within 72 hours after consumption (U.S. Food & Drug Administration). If toxicity occurs a close watch is kept on the patient to monitor liver and kidney functions, which can be damaged by the toxins.