Chemotherapy Case Study

Earlier studies on mice have shown that the poison can specifically attack and destroy tumor cells.

Compound 3a was selected by the National Cancer Institute (NCI) USA for anticancer screening with the NCI code D-785902/1. Compound 3c was found in the already tested cancer candidates in the NCI data base under NCI code NSC: 650353[42]. Both candidates were screened on human tumour cell lines at 10-5 M at the 60-Cell-Line Screenings of the Developmental Therapeutics Program (DTP) of the National Cancer Institute (NCI, Bethesda, Maryland, USA) under the drug discovery program of the NCI. The 60-cell-line-screening of the NCI includes 60 different tumour cell lines, the nine various organs and tumour types derived (leukaemia, non-small-cell lung cancer, colon cancer, CNS cancer, melanoma,

Losing hair can be a very traumatizing experience for children who have cancer and are going through chemotherapy. Holly Christensen is making fairy tales come true for little girls battling cancer by making Disney princesses’ wigs for them.

According to the National Cancer Institute by 2002 and other cancer organizations, there are about 250000 to 400000 people who receive chemotherapy each year. Health care professionals know the side effects that the chemotherapy cause and they understand the benefits that they offer. They prevent, detect, diagnose, control, and treat the cancer by minimizing the psychological impacts of the disease and its treatment, and to improve the patients’ quality of life.

Cytotoxic chemotherapy was first discovered during World War II by Gilman and Philips when they perceived the effect that nitrogen gas (used during WWI) had on the number of human cells proliferating and recognised this as a potential treatment for cancer. From this discovery, biotherapy was born helping to increase our knowledge in how to achieve cell death and tumour control through use of cytokines and monoclonal antibodies (Young et al, 2006). Cancer is often described as unregulated cell growth through a multistep process (Brighton et al, 2005). Brighton (2005) describes the ‘Hallmarks’ of the cancer cell as needing to acquire these six steps in order to develop: ‘self-sufficiency in growth signals, insensitivity to antigrowth signal, avoiding apoptosis, limitless replicative potential, angiogenesis and tumour invasion/ metastasis’. These six Hallmarks of Cancer describe the pathogenesis that a cell undertakes until it develops into a tumour which can then potentially become malignant (Hanahan et al, 2011). While normal cells can control their own proliferation that allows a homeostasis amongst cells, that new cells are born once the old cells have died ensuring that there are enough cells available to fulfil the task at hand. Cancer cells are more neurotic, they interrupt the normal signalling pathway within the healthy cells, and then they begin to grow uncontrollably invading the

I was only able to locate where the patient was on two regimens which were the Herceptin, Perjeta, Taxotere, Carboplatin used in combination with each other and the FEC regimen. I was not able to locate any authorization for Herceptin used as a single agent.

I woke up this morning in kind of a bad mood. I went to work and tried to hide it, listened to my client talk about her troubles, receive a call with a last minute cancellation and became even more cranky. Then I went to Robeks to pick up a smoothy for a friend.

Chemotherapy has rapidly changed throughout the years. In today’s society more treatment options have risen and created better survival rates than chemotherapy. Chemotherapy is a process in which chemicals are injected into the body intravenously for the treatment of cancer. The history of chemotherapy is quite interesting and surprisingly, the drug first used (mustard gas) was not intended to treat cancer. It was used in World War I and was studied more closely during World War II. “ During a military operation in World War II, a group of people were accidentally exposed to mustard gas and were later found to have very low white blood cell counts. It was reasoned that an agent that damaged the rapidly growing white blood cells might have a

Cancer is one of the leading causes of death today. There are a variety of different treatments for cancer such as surgical removal, chemotherapy, hormone therapy, and radiation. Chemotherapy is the most common approach it kills the cancer cells by drug toxicity or preventing cell division (Jabir et al., 2012). The issue with Chemotherapy is that it is rarely successful. The radiation approach kills cancerous cells, but it also damages the surrounding healthy cells. However, newer techniques are being developed to just attack the cancerous cells. There is a need to find a cancer treatment approach that does not kill the healthy cells along with the cancerous cells. The answer to solving this challenge lies in the successful application of

Bacteria accurately target tumors, actively enter tissue, simply recognized and controllably produce cytotoxicity. also, Several popular cures such as chemotherapy and radiation are poisonous for healthy tissue and not fully damage every cancer cells. Three main reasons for these difficulties are deficient tumor targeting, poor tissue invasion and insufficient toxicity to each cancer cells. These disadvantages limit qualified therapy and are linked with the rise in morbidity and mortality.

Conducting medical research on cancer patients for the effectiveness of high-dose chemotherapeutic agent like methotrexate(MTX), and then dosing leucovorin to neutralize the effects of the toxic chemo, should this be done supervised for accurate documentation and safety in a hospital or should the patient be allowed to self-medicate with the leucovorin at home, for the comfort and convenience of the already ill patient.

One of the reasons why the children in the cancer ward have a bald head is chemotherapy. Chemotherapy drugs are very strong and powerful medications that attack growing cancer cells as well as other growing cells in your body. That includes hair roots. Baldness is not permanent. After treatment your hair will take 4 or more months to grow back. It may come back a different color and texture but that is not permanent.

19. He died today. I knew he would because he refused to undergo chemotherapy. It's kind of ironic how life works he was an oncologist and now he was dying of a diagnosis he had given to thousands of strangers. I don’t want to admit it but I miss him. He knew I would. I hope he did. I don’t know what to do now. I’ve faked my own death. I have nothing left

Last Wednesday, I shadowed Jennifer, Amy, and Laura on the eighth floor Infusion Clinic for four hours. Jennifer was the first nurse there that morning. She graduated from Marion University and developed her IV skills with a mentor while working in Interventional Radiology. On that unit, a lot of the patients had Chronic Kidney Disease, so hand IVs were performed to save patients’ arm veins for dialysis. She does not have any additional certifications related to IVs. She enjoys working in the infusion clinic because she loves oncology. Her number one tip for starting IVs is to always try on a patient because facing a challenge is a great way to learn.

In vitro: WEHI-539 was found to have high subnanomolar affinity and could potently and selectively kill cells by antagonizing the prosurvival activity of BCL-XL (IC50 = 1.1 nM).