DNA Vs. Epigenetic Synthesis

Epigenetics is a study that entails the heritage changes in gene expressions, which includes both the active and the inactive genes; the changes do not involve changes to the underlying DNA sequence. Meaning, it is a change in phenotypes without the differences in genotypes and consequently, affect how the cells read the genes. The epigenetic modification is a natural occurrence but apparently can be influenced by other several factors, including diseases, the environment, and age. Epigenetic changes can result in adverse damages and can end up causing infections such as cancer (Barton et al, 2016). This paper looks at what epigenetics entails, the hidden life of our genes, how food affects genes and how one can elongate life by improving health status.

Both DNA and life’s experiences are influential in human development. Understand the unchangeable DNA and use experiences (including training) to achieve desired traits.

Epigenetics is the future of science. It has evolved from being a science that very few believed in, to one that will shape medicine as it is known. As the Human Genome Project began, the goal was to determine which genes controlled what phenotypes in a human. After all the genes were identified and mapped, the expression of the genes that the scientists had just discovered was also beginning to be analyzed (EPIGENETICS). Although every gene had been identified and associated with a function, there were genes that if not expressed or not turned on, would create a different scenario. That is, the idea that the genotype of an individual would determine their phenotype was reinforced. Epigenetics however is the study of the switching on or off of the genes responsible for a particular action (Feinberg). For example, all of the organs of a single person have the exact same DNA as the others, yet a lung looks drastically different from a kidney. This is due to the expression of the genes responsible for creating a specific organ. If scientists are able to control the switching on and off of these genes, then many extraordinary possibilities exist.

Moshe Szyf, an epigenist informed us through his Ted Talk, “How life experience is written into DNA,” of our genes and how they are “combined of two components” (15:17). He used rhetorical strategies to engage his audience in understanding the view of DNA through an epigenetics perspective. He provides many examples of experiments performed which show these layers of information. The two layers include the old information from millions of years of evolution and the epigenetic layer which includes the open and dynamic set up of a narrative that is interactive and allows us to control our destiny.

Burying the dogma of the genomics fixity, epigenetics demonstrates that our lifestyle changes our genes and we pass these mutations on. This discovery opens up new prospects of cure for many diseases. At the level of our genome, there are two kinds of genes: exons which are genes that are expressed and induce the production of certain proteins, and introns which are genes that are eliminated in the transcription of the RNA, and which therefore are not expressed. Environmental conditions could change that by opening introns or closing exons with all possible intermediate situations between these two extremes, from this perspective, epigenetics would correspond to an open or closed switch, to varying degrees. These different positions of switches then open the door to many combinations of genes. This seems to go against a current scientific dogma that considers the genome of a person is inherited from the parents and then remains fixed and determined for his entire life. Moreover, according to the evolutionary theory of Darwin, if mutations occur in a species facing a changing environment, these changes occur only over extremely long periods of time that often number in the thousands or even millions years. Epigenetics shows that on the contrary, these changes are a natural way and very common in nature. With Epigenetics: we can change our

Genetics is a field of science that has long been studied, but researchers and scientists have discovered a new branch that changes the way genetics and evolution has been looked at before. Deepak Chopra and Rudolph E. Tanzi skillfully describe this new subject in their book Super Genes. The book includes information on the history and discoveries of epigenetics, the changes the readers can make to unlock and harness the power of their genes, and the research and experiments that prove the benefits of those changes. Ultimately, the purpose of Super Genes is to inform the readers that they can control their own genes, despite preceding understandings of biological destinies, by making favorable lifestyle choices that leans towards the state of optimum health and well being.

A related phrase described by Waddington to help elaborate the phenomenon of epigenetics, the ‘epigenetic landscape’ attempts to explain how identical genotypes could result in a wide variety of phenotypic variation through the process of development. This epigenetic landscape can be dynamic – capturing genetic, environmental, and cell lineage effects – and has been shown to be at least partly heritable. (Szyf, M. (2015) Nongenetic inheritance and transgenerational epigenetics. Trends Mol. Med. 21, 134–144). The epigenetic code is hypothesized to be a defining code in every eukaryotic cell consisting of the specific epigenetic modifications in each cell. While in one individual the genetic code in each cell is the same, the epigenetic code is tissue & cell

In fact, epigenetics opens wide opportunities to enhance studies in the field of medicine, biology, zoology and other fields of science. In some directions, epigenetics can help to make a breakthrough in the development of some fields of science. This is why one should never narrow the scope and potential of epigenetics. The understanding of chemical reactions and genome activation and deactivation are extremely important for understanding of fundamental principles of the development of living beings and their functioning in the course of their

The genome is the complete set of an individual’s inheritable traits or it’s DNA. As a fetus develops, signals are received that cause incremental change in the gene expression patterns. The DNA in our bodies is wrapped around proteins called histone. The histone and DNA are covered in chemical tags. This structure is called an epigenome. The epigenome shapes the structure of the genome. Epigenetic marks are modifications of DNA and histones. The epigenome tightly wraps inactive genes and allows active genes to be more easily accessible. The epigenome adjusts specific genes in response to our changing environment. The programming of neurons through epigenetic mechanisms is critical in neural development. A type of cellular memory is formed when those changes occur. These are epigenetic tags. Each tag records the cell’s experiences on the DNA. This is to help stabilize gene expression. Over time, and with thousands of different experiences, an epigenetic profile forms for each cell type. Each one is unique, with a distinct identity and a specialized function. A flexible epigenome allows us to adjust and learn from our mistakes. The epigenome responds to signals. These signals come from a variety of places. From fetal development to old age, our epigenome is effected by our environmental factors.

The DNA Mystique looks into the power of the gene in today’s society. Dorothy Nelkin and Susan Lindee (1995) describe the evolution of the gene as a cultural icon. Society puts a huge emphasis on understanding everyday behavior and the “secret of life” through genetic essentialism. According to Nelkin and Lindee genetic essentialism “reduces the self to a molecular entity, equating human beings, in all their social, historical, and moral complexity, with their genes” (p. 337). DNA is used as a way to define the individual’s true self and understand the evolution of a person’s identity. Nelkin and Lindee discuss the intersection of science and popular culture to shape the cultural meaning of the gene (p. 338). They lay out a timeline of genetic mapping and the use of genome research to determine future outcomes.

Before conducting research and watching numerous informational videos on epigenetics, I would have never believed that when my grandmother was my age, she made dietary decisions that have affected me. Technically speaking, epigenetics simply means above genetics. In other words, epigenetics is the traits that you and I inherit, but do not necessarily necessitate the sequence of genes. I took me a while to actually grasp the concept until I thought of it from a musical perspective. Imagine our DNA helix strands as a musical score. There are different music notes as there are genes. If someone were to play Beethoven’s Symphony Number 5 correctly, it would sound the same every time. Basically, if one note is changed, the whole musical piece

A roadmap to our future is predetermined by our genetical makeup. However, can external influences such as environment and lifestyle unlock who we are? The study to understand heritable changes in genetical expression is called Epigenetics. Héctor González-Pardo and Marino Pérez Álvarez(2013) describes Epigenetics as the examination of the heritable complex genetical alterations that are shaped by environmental factors which don’t cause changes to the DNA Sequence. In other words, different cell/organism must use the same script in different ways. The study of epigenetics explores the idea that DNA is a script and not a manual. Accordingly, we can positively influence our lives as well as the lives of our offspring by leading a healthy lifestyle.

The observatory sense demonstrated by scientists to eventually conclude that inheritance is more than genes and the DNA sequence is both commendable and insightful. It was surprising to find out that genes are not the only genetic components passed from one generation another. They are not the only one that influences transgenerational changes. More surprising was the revelations that the human genome has more than 30,000 genes that could be switched on and off due to environmental stimuli. Essentially, genes experience epigenetic changes. These chemical labels accrue over time and influence the turning on and off (BBC Channel TV, 2015). The switching on and off of genes causes humans to have different kind of cells. It is notable that the effect of the environment is a major factor in explaining the hereditary patterns and the

How would you feel if you knew that the food you eat could affect your future offspring? The things you do today could affect your child tomorrow. The science of epigenetics examines this concept. Epigenetics is the study of how heritable genes are influenced by environmental factors and the lifestyle one chooses. To get a deeper insight into the great world of epigenetics, we will describe it’s origin, how it affects people, and how it can potentially help in the future.

The ancient origins of the term "epigenesis" date back to Aristotle, which described this phenomenon, scilicet each organism is gradually originated from an undifferentiated mass by a series of steps during which new parts are added, in contrast with the preformistic theory that state that development of an organism simply consists in the growth of an already performed entity.