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Dealing With Huntington's Disease

Decent Essays
Huntington’s disease is a neurodegenerative disorder that slowly breaks down somatic tissues. This degeneration causes a mass amount of chorea, change in mental functioning, change in behavior, decreased memory, along with other serious psychological problems. Since the mechanism of the disease is still not fully understood, there is no cure for the disease, but there are several therapies and medications available. All of the medication and treatment available only help to manage symptoms; they are just stalling the progression of the symptoms but not the overall disease. Medications that have shown an ability to slow the effect of symptomatic onset of Huntington’s disease are currently being tested in clinical trials. One of these medications…show more content…
Being diagnosed with Huntington’s disease is equivalent to being told the long painful process that will eventually kill you. This is why there is a suicide rate of about 25% for those diagnosed with Huntington’s disease. There are counseling option available such as group sessions or personal doctors in order to help people cope with the idea of death. Along with counseling, there are also a number of antidepressants such as fluoxetine, citalopram and paroxetine that can help improve mood. A major problem with these drugs is that many of their side effects increase the chorea within users. These side effects are the main reason why the smallest dosage possible is prescribed, if prescribed at all. (NHS). Family members of Huntington disease victims also often need similar counseling because they have to watch their loved one go through this degeneration.…show more content…
This is a common repeat that all people have, 35 or less is considered normal, but if the repetition goes beyond that it is linked to Huntington’s disease. (U.S. Library of Medicine). In order to help treat this disease as a whole, I would propose a drug that can help to limit the number of CAG repetitions during production. One way of doing this is to have the drug target the ribosomes during their production of amino acid chains. If it can be possible to limit the CAG repetition here to no more than 35, then is can be possible to prevent Huntington’s disease before it happens. Since a person can be tested at any point in their life, this drug can be taken if a person tests positive in order to prevent the onset of Huntington’s disease. Another way to try and treat the disease is to have the drug target the rough endoplasmic reticulum, which manages the folding of proteins and recognizing any errors within its process. If the drug can promote the rough ER to target proteins with a large CAG repeat for degradation, then the protein cannot reach a toxic level. This type of treatment could be used to prevent the disease or halt the process if it has already
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