Dementia's Athologic Study

The amyloid cascade hypothesis is the most widely accepted of the AD pathogenesis hypotheses. Its principle is that the accumulation of Aβ plays a major role in AD pathogenesis, and the disease is analyzed as a series of abnormalities in the process and secretion of the amyloid precursor protein (APP), where an inequality between production and clearance of amyloid β is the triggering event and the most important factor responsible for other abnormalities observed in AD (Hardy et al, 2002; Cummings et al, 2007). Amyloid β is a peptide with high resistance to proteolytic degradation. It consists of 37–43 amino acids with different isoforms (Deane et al, 2009). Aβ is the result of sequential cleavage of the amyloid precursor protein (APP), generating

Alzheimer’s disease (AD) is a progressive and fatal form of dementia, frequently seen in the elderly altering their cognition, thought process and behavior. AD is reported in about half of patients that have a dementia diagnosis; one study states that about 10.3% of the population over 65 years is affected by dementia with an increase to almost 50% over the age of 8 (Beattie, 2002). Alzheimer’s disease is not a normal part of the aging process in humans, but rather found in a group of diseases that affect the brain leading to a decline in mental and physical control. AD when diagnosed has a very slow and gradual course, initially affecting the individual’s short term memory (Beattie, 2002). Alzheimer’s disease is the 6th leading cause of death, affecting more than five million people in the United States and is also one of the most common forms of dementia. Dementia can be defined as a disorder of progressive cognitive impairment severe enough to affect daily functions of an individual’s life (Fillit, et al., 2002).

Throughout this line of study, Alzheimer’s disease is a specific form of dementia. According to Alzheimer’s Association, dementia is a general term for a decline in mental ability that is severe enough to hinder daily life. Memory loss is a symptom of dementia and the most common type of dementia is Alzheimer’s. One of the most common and severe symptom of Alzheimer’s is difficulty remembering newly learned information. The changes of Alzheimer’s normally begin in the part of the brain that affects learning (Overview Alzheimer's Association). Some other symptoms of Alzheimer’s include gradual memory loss, the decline in capability to carry out everyday tasks and the loss of their language skills. According to Bialystok the rate of

Alzheimer’s Disease is a disease of the future. With the growing aged population, this disease, which affects primarily the elderly, will become of increasing relevance to the medical profession. Also, the high frequency of Alzheimer’s, and the high cost in labor, money, and material of caring for its victims shall put considerable burden on the society as a whole. Here, however, these issues are not going to be debated. Instead the pathology of Alzheimer’s will be reviewed to the extent it is known today.

Alzheimer’s disease (AD) is a progressive and fatal form of dementia, frequently seen in the elderly altering their cognition, thought process and behavior. AD is reported in about half of patients that have a dementia diagnosis; one study states that about 10.3% of the population over 65 years is affected by dementia with an increase to almost 50% over the age of 85. (Beattie, 2002) Alzheimer’s disease is not a normal part of the aging process in humans, but rather found in a group of diseases that affect the brain leading to a decline in mental and physical control. AD when diagnosed has a very slow and gradual course, initially affecting the individual’s short term memory. (Beattie, 2002)

An estimated 47.5 million people suffer from dementia. Every 4 seconds one new case of dementia is diagnosed. Dementia is a term that describes certain symptoms such as impairment to memory, communication and thinking. It is a group of symptoms and not just one illness. Even though one‘s chance of getting dementia increase with age, it is not a part of aging. Dementia is usually diagnosed after a series of assessments that includes a physical evaluation, memory tests, imaging studies and blood work. It affects three aspects of one’s mental function, cognitive dysfunction (Problems with memory, language, thinking and problem solving), psychiatric behavior (changes in personality, emotional control, social behavior and delusions) and difficulties with daily living activities (driving, shopping, eating and dressing). “The median survival time in women is 4.6 years and in men 4.1 years” (Warren, 2016).

Throughout history there have been reports of decreased memory and mental deterioration that accompanied old age. Alzheimer’s disease (AD) was named after Dr. Alois Alzheimer who described the symptoms in a woman in Germany in the 1907 but it was not until the 1970’s that AD was considered to be a major disorder and AD continues to be a major health concern worldwide (Reger, 2002).

Alzheimer's disease was described for the first time by Alois Alzheimer in Nov. 1901 when he met his 51-year-old patient Auguste D who had a progressive memory loss, cognitive decline and movement retardation. After the death of Auguste, Alzheimer had sent her brain to Munich for a thorough study to find out later that there are two lesions in the brain: senile plaque and neuro fibrillary tangle1. Senile plaques are extracellular deposits of amyloid-β and the majority species of it is Aβ40 and Aβ42, whereas the neuro fibrillary tangles are composed of defective tau filaments that are joined together inside neurons to form a round shaped tangle2.

Alzheimer’s disease (AD) is a form of dementia that causes problems with memory, thinking, and behavior. AD typically involves the development of a progressive neuropsychiatric disorder that is characterized by gradual memory impairment, loss of acquired skills and emotional disturbances (Lee, Y. J., Han, S. B., Nam, S. Y., Oh, K. W., & Hong, J. T.). Every 67 seconds an individual in the United States develops AD. AD is the sixth leading cause of death in the United States. There are 5.3 million Americans diagnosed with AD (Latest Alzheimer's Facts and Figures). AD is one of the few degenerative diseases that cannot be prevented, stopped, or cured (Latest Alzheimer's Facts and Figures). Post-mortem examination of the brain of AD patients usually

“What is Alzheimer’s disease (AD)?” Alzheimer’s disease is the most common form of dementia that affects an individual’s memory, cognition, and behavior disturbances that ultimately diminishes their quality of life.1-2 Dementia is not a specific disease it is a general term for a variety of symptoms that affect memory and intellectual thinking that causes difficulty in our tasks of daily living.(5) The confusion between these two terms is extraordinary. It’s helpful to think of dementia as the symptom and to think of AD as the cause of that symptom. Although, there are many causes of dementia for the purpose of this paper, Alzheimer’s will be the only one discussed.

According to Lu and Bludau (2011), Alzheimer disease is a degenerative disease of the brain that can lead to dementia and impair all brain functioning. Biologically, Alzheimer’s disease is believed to be caused by abnormal plaques called amyloid plaques, which are a buildup of protein fragments that are thought to be damaging to the brain cells. However, scientists are still unsure if this buildup actually cause the disease or is a result of the disease itself. This disease can also be a result of a genetic mutation, increasing individuals with the gene mutation risk as much as eight times higher than individuals

Alzheimer’s disease (AD), a form of degenerative, fatal dementia, is characterized by progressive cognitive decline. While AD is the most common form of dementia, its prevalence has only recently been recognized. When Alois Alzheimer first described the sequence of changes in 1907, physicians believed the disease to be an extremely rare, mid-life condition. It wasn’t until the 1970’s that the same types of changes were shown to occur in both late- and early-onset forms (Cavanaugh et.al. 2008). As such, almost all knowledge of AD has been learned within the past several decades, with new discoveries being reported almost daily. It is now estimated that Alzheimer’s accounts for as many as 60% of all dementias and affects more than 500,000

“Alzheimer’s disease (AD) is the most common form of dementia, a neurologic disease characterized by loss of mental ability severe enough to interfere with normal activities of daily living, lasting at least six months, and not present from birth.’ AD usually occurs in old age, and is marked by a decline in cerebral functions,

Kevin Arnold once said, “Memory is a way of holding on to the things you love, the things you are, and the things you never want to lose.” Memories are the things hold on to in life. Whether it’s bad or good, memories are engraved in us and as we carry them through our everyday lives they become a part of us. But what if as times goes by, those memories start to disappear? Imagine that the things you held onto for years could no longer be conjured up no matter how hard you tried. Or even worse, you begin to lose your language skills, ability to recognize familiar things and in turn, start to feel paranoid and confused constantly. For those who suffer from Alzheimer’s, as they age they experience a serious deterioration in one’s self.

Alzheimer’s disease (AD), is a type of dementia that no one would ever want their grandmother or grandfather to suffer from, as it destroys memory and other important mental functions of its sufferer. Alzheimer's disease is currently ranked as the sixth leading cause of death in the United States. While the age 65 and older is its target age, it has consumed the lives of over 1.9 million people. The brain begins to show signs of damage in the hippocampus, the part of the brain essential in forming memories. As more neurons die, parts of the brain then begin to shrink. By the final stage of Alzheimer’s, damage is widespread, and brain tissue has shrunk significantly. The idea that Alzheimer’s disease is related to age in 1974 was introduced