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Different Stages Of Cell Division

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1) Cell division is typically explained through the progression of 4 distinct phases, G1, S, G2, and M, and can be tracked through CDK complex concentration ranges. CDKs are cyclin-dependent kinases, which regulate the cell cycle of eukaryotic cells; as suggested by the name, protein kinases are an enzyme that is dependent on cyclin for the regulation of cell division through the addition of phosphate groups. The different stages of the cell cycle correlate with different levels of cyclin and act as a threshold that once reached, triggers a phase transition. For example, for a cell to move out of G2 phase into M phase, Cyclin B interacts with the CDK1 complex, and causes phosphorylation to stimulate the phase shift; however, if the stage is not complete, the whole process slows down to accommodate the discrepancy in CDK complexes (Nelson Education, figure 9.17, page 191). This can be caused by several things, such as the presence of damaged or deformed DNA, or externally through contact inhibition, where a delay in phase shift is caused by partial or incomplete contact of all cells. If there is only partial cell contact, contact inhibition will typically prevent progression past the G1 phase until there is complete cell contact, which can be reflected in variable levels of the CDK complex(Nelson Education, page 191). Overall, CDK regulates cell division through the combination of CDK and cyclin, the activation of protein via a phosphate group that triggers a phase change,

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