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Drosophila Melanogaster

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For more than a century Drosophila Melanogaster has been one of the most intensely studied organisms in biology. Thanks to being sexually dimorphic, having short generation periods, a high fecundity, and only four pairs of chromosomes, Drosophila Melanogaster are exceptional model organisms (Roach et al, 2008). Drosophila Melanogaster broke into the forefront of biological research in the early 20th century, when Dr. Thomas Morgan, using Drosophila, founded contemporary genetics with major discoveries concerning sex-linked inheritance and phylogenetic impact of gene mutation (Metcalfe et al, 2013). Today Drosophila Melanogaster is a staple in classrooms and laboratories alike; serving as not only as an observable means of studying classic Mendelian genetics, but also a model organism for cutting edge medical and scientific research.…show more content…
With a basic understanding of Mendelian genetics and application of genetic tools, characteristics of these mutations were assessed. The studied mutations were to the vestigial gene and eye pigment gene with phenotypes expressed as ectopic wings and white eyes respectively. Through cross breeding of the parent generation, and subsequent daughter generations, along with manipulation of sex and phenotype being crossed, the inheritance pattern, chromosomal loci, and whether the mutation is sex link can all be discovered. Given the results of F1 crosses, the Vg gene is expressed following an autosomal inheritance pattern while being recessive to a dominant WT phenotype of normal wings. The white-eye phenotype is expressed as a sex-linked trait as it is exclusively expressed in male flies. This hypothesis cannot be confirmed until the F2 generation is crossed and
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