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Effects Of Renal Impairment On The Pharmacokinetics Of Prucalopride

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(1) State the chosen journal article in the Vancouver referencing format.
Smith WB, Mannaert E, Verhaeghe T, Kerstens R, Vandeplassche L, De Velde VV. Effect of renal impairment on the pharmacokinetics of prucalopride: a single-dose open-label Phase I study [Internet]. 2012 [cited 2015 Sep 01]; 6: 407-415. Available from: www.ncbi-nlm-nih-gov.ezp01.library.qut.edu.au/pmc/articles/PMC3529624/pdf/dddt-6-407.pdf

(2) What were the compounds (and the derivatives if any) under investigation? Provide a brief description about their pharmacology, and the potential uses in medical treatments.
This study concerned the drug prucalopride. Owing to its strong gastrointestinal prokinetic activity, prucalopride is indicated for the symptomatic…show more content…
(3) List the objectives of the pharmacokinetic study. What can we learn from studying drugs in the selected population?
The objective of this pharmacokinetic study was to evaluate the pharmacokinetics of prucalopride in individuals with renal impairment. By studying drugs in patients with renal impairment, a greater understanding of the effect of decreased drug renal clearance on drug doses can be made. This is particularly important in the current aging population, whereby decreased renal function is a natural consequent of old age, as is the increased prevalence of constipation associated with drug treatments and lifestyle changes. Considering 60% of prucalopride is excreted unchanged in urine, renal excretion is one of the most important routes of elimination for prucalopride. This further validates the importance of this study in the selected population.

Although prucalopride is not currently approved for use in men, this pharmacokinetic study involved both men and women. This enables results of the study to be applicable for potential future use in men.

(4) Briefly describe the study design including information about the dosage and the route of administration.
The study involved 34 men and women aged 18-75 years old. They were each classified by renal function:
• Normal renal function (creatinine clearance ≥ 80mL/min/1.73m2)
• Mild renal impairment (creatinine clearance 50-79mL/min/1.73m2)
• Severe renal impairment (creatinine clearance ≤
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