Endocrine Disruptors are Manmade Chemical that Interfer with the Endocrine System

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Endocrine disruptors are typically man-made chemicals that interfere with the endocrine system; they are known to cause cancerous tumors, abnormal growth patterns, birth defects and other various developmental disorders. The crucial period of development of most organisms is the transition from a fertilized egg and into a fully formed fetus. Studies performed on cells and animals, have shown that Endocrine Disrupting Chemicals, EDC, pose the biggest risk in fetus’ prenatal and early postnatal development; it is during these stages that the organ and nervous systems are forming. EDCs can be found anywhere from household products to industrial products; they interfere with the synthesis, secretion, transport, binding and elimination of specific hormones found in the body (Luster et al, 1987). The specific hormones that are being altered or eliminated are responsible for growth, behavior, fertility and the maintenance of homeostasis. Previous research has shown that Phosphatidylserine (PS) and Caspase 8 both help to inhibit apoptosis; however studies have yet to use DNA laddering to look at the specific mechanism that causes apoptosis. The goal is to use DNA laddering to identify the mechanism that causes programmed cell-death. To do this research, we are asking for $1,000.00, in order to provide us with the proper instruments and materials.

Project Description
Recent studies have demonstrated that apoptosis can be seen through the use of cell counts, Phosphatidylserine,

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