Essay On Congenital Hypopituitarism

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Congenital hypopituitarism is a rare condition and refers to absence or reduction in function of two or more hormones produced by pituitary gland. When all pituitary hormones are affected the term panhypopituitarism is used. It can be congenital or acquired. Congenital hypopituitarism is potentially fatal in newborn period but treatable if the diagnosis is made early. Presentation of hypopituitarism can vary in different patients. In our case patient presented with septic shock, persistent hypoglycemia , seizures, hypothermia and jaundice
Blizzard and Albert’s3 first reported Congenital Hypopituitarism in 1956, which described a newborn with microphallus and cryptorchidism, presented with apneic and cyanotic spells in the first few hours of life and died within 24hours.. Our patient presented in the one and half month age hours of life in septic shock with …show more content…

In our infant the only clinical clue was microphallus.
There can be many life threatening complications if not treated early. In one case study congenital hypopituitarism presented with renal failure. Patient developed renal failure due to initial cardiovascular compromise related to hypotension4. Sometimes microphalus is only the presentation5. It can also be associated with midline alterations6 .
Congenital hypopituitarism should be followed regularly. It has been suggested these patients have low IQ compared with other normal children7. This case report highlights the importance of prompt and thorough investigation for unexplained hypoglycemia in the newborn. It also emphasises the fact that the association of hypoglycemia and microphallus in the male neonate is presumptive evidence of congenital hypopituitarism. To our knowledge this is the first report of association of late onset congenital hypopituitarism with septic shock and

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