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Failure And Treatment Of Heart Failure

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Abstract: Heart failure affects over 5 million people and carries a high rate of mortality. Ivabradine, a new agent has been added to the current medical options for managing heart failure. It is a selective inhibitor of sino-atrial node and slows its firing rate, prolonging diastolic depolarization without any negative inotropic effects. In 2006, BEAUTIFUL trial evaluated patients with stable coronary artery disease and heart failure and found a significant reduction of coronary events, coronary revascularization and fatal and nonfatal myocardial infarction in patients with heart rate of >70 bpm. SHIFT trial observed patients with chronic heart failure with low ejection fraction and showed significantly reduced rate of hospitalization and deaths due to heart failure with Ivabradine. These trials resulted in this agent’s approval in Europe for chronic stable angina and chronic heart failure and in USA for reducing hospitalizations with chronic heart failure. Ivabradine has also been tried in other conditions like inappropriate sinus tachycardia, cardiogenic shock and is in phase II trial for patients with newly diagnosed multiple organ dysfunction syndrome. Background and Mechanism of Action Heart failure is a common cardiovascular condition affecting over 5 million individuals in USA. About 400,000 to 700,000 new cases of heart failure are diagnosed each year and carry a mortality of up to 250,000 per year (1). The current treatment options for managing heart

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