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Fluid Mosaic Model Of Membrane Structure Essay

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Fluid Mosaic Model of membrane structure, proposed by Singer and Nicolson in 1972, explains that cell membranes are composed of a lipid bilayer having globular proteins embedded in the bilayer. Detail study shows that cell membranes consist of 4 major components:1) Lipid bilayer, 2) Transmembrane proteins or Integral membrane proteins, 3) Interior protein network and 4) Cell surface markers. The main fabric of the membrane consists of amphiphilic phospholipid molecules. Integral proteins, the second major component, are integrated completely into the membrane with their hydrophobic membrane-spanning regions interacting with the hydrophobic region of the phospholipid bilayer. Similarly, Carbohydrates, the third component are found on the exterior surface of cells having bound either to proteins to form forming glycoproteins or to lipids, to form glycolipids. Proteins that bound in the membrane can drift around in the cell membrane, referring as ‘fluid mosaic model’. Membrane fluidity is governed by several factors like molecular composition and temperature. Increase in temperature results in increase in membrane fluidity and vice versa. It is important to an organism to minimize the effect of temperature and maintain its fluidity, a cell can make changes to the structure of its membrane. For instance, double bonds in the hydrocarbon chains in the phospholipids or short chains makes the membrane more difficult to pack together, thereby increase the membrane fluidity. Lipids

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