Fluorometholone And Other Corticosteroids For Inflammation
2282 WordsDec 6, 201410 Pages
FLUOROMETHOLONE AND OTHER CORTICOSTEROIDS FOR INFLAMMATION
SUMMARY: Cap like structures that appear on the top of both kidneys are referred as adrenal glands. As they are located above the kidney, they are also referred as ‘suprarenal glands’.1In the transverse section of adrenal gland, two regions can be identified - medulla and cortex.1The medulla region is innervated by sympathetic nervous system which helps in production and release of two important neurotransmitters - Epinephrine and Norepinephrine.1 The cortex is responsible for synthesis and release of three different hormones namely - mineralocorticoids, glucocorticoids and androgens.1 Mineralocorticoids and glucocorticoids are collectively referred as corticosteroids.…show more content…
During this trial and error procedure of adding and removing different functional groups, structure activity relationship was established which provided us knowledge about the contribution of different functional groups towards efficacy of the drug or towards unwanted effects. Certain molecular modifications helped in achieving targeted drug delivery for different skin disorders and ophthalmic conditions. The data obtained from the preclinical and clinical studies serve as a strong evidence for effectiveness of these synthetic corticosteroids.
STRUCTURE ANALYSIS: Fluorometholone is a synthetic topical corticosteroid consisting of four fused ring systems out of which three rings are of cyclohexane and one of cyclopentane. The three cyclohexane rings are named A, B and C respectively. Figure 1: Structure of Fluorometholone
These three rings form the per-hydro derivative of Phenanthrene to which the fourth cyclopentane ring or D ring is fused. Hence, we can also say it is cyclopenta[a]phenanthrene derivative.3The steroid nucleus can be classified into several classes depending on the chemical constituents. If we analyze the structure of Fluromethalone, it specifically contains the Pregnane4 – Steroid Nucleus consisting of 21 carbons in its skeleton. Moreover, the pregnane nucleus is a planar ring system with two stereo-isomeric forms depending on the spatial arrangement of hydrogen on C-5. Both α – F at C-9 and = at C 1,2