Glucosamine: Osteoarthritis And Crohn's Disease

Osteoarthritis is often associated with degeneration and destruction of articular cartilage. Pathophysiology of the disease is complex which involving of pro-inflammatory cytokines and growth factor that affects the joint homeostasis (McNulty et al, 2013). Recent studies shown increase production of pro-inflammatory cytokines may play a critical role in pathogenesis of osteoarthritis (Bondeson, 2006) which will be discussed in later part.

Glucosamine stimulates production of glycosaminoglycans and proteoglycans, the two essential building blocks of cartilage. Advocates of the treatment say that artificially synthesized glucosamine supplements can jumpstart glucosamine production within joints. Choindroitin is made of many of the same molecules as glucosamine, and essentially serves the same purpose. The long-lasting pain relief and functional improvements that are reported by users of the supplement come as a result of anti-inflammatory agents, an increase in cartilage building activities, and a reduction in the enzymatic destruction of cartilage. Along with a termination in the progression of joint damage, reversal of damage is also highly likely. The rapid pain relief upon initiation of a glucosamine

Non-steroidal anti-inflammatory drugs (NSAIDs) are the foundation of medical treatment for osteoarthritis (OA). It is the most common medication taken by an individual experiencing pain due to this degenerative joint disease. Not to mention, NSAIDS are prescribed for pain management in older adults since they are more efficacious than acetaminophen with the absence of central nervous system side effects of opioids

Osteoarthritis, the most common type of arthritis, is most prevalent in older patients. Osteoarthritis is a degenerative bone disease due to the gradual loss of cartilage. A primary type of osteoarthritis is hip arthritis where it is caused by joint injury, increasing age, and being overweight (“Hip Osteoarthritis,” n.d.). However, osteoarthritis can also be caused by immature joints, inherited defects in cartilage, and extra stress on a patient’s joints (Hip Osteoarthritis,” n.d.). As a result, hip arthritis becomes a huge detriment in patient’s social, emotional, physical lifestyles. In order to treat hip arthritis, doctors choose from a variety of non-drug treatments, medications, and surgeries. Uniquely, I was inspired to research about the treatments of hip arthritis because my very own brother was pronounced with hip arthritis a few years back. Therefore, his determination to battle this disease encouraged me to investigate about the treatment of hip arthritis.

There are very few, if any, side effects to taking glucosamine and chondroitin joint supplements. There is also some evidence that NSAID's can actually INCREASE the progression of arthritis! This is a big risk to take if you are trying to reduce your arthritis symptoms. Glucosamine chondroitin on the other hand can protect the cartilage leading to long term relief from arthritis symptoms.

Glucosamine chondroitin is a widely used supplement product for treating canine osteoarthritis without the risks of negative side effects.

In only severe case do extreme symptoms present which are very rare. There is no complete cure to any of the condition however using Meloxicam can decrease pain as well as lessen the symptoms. Meloxicam is used to treat both of these conditions for an extended period of time, but osteoarthritis is treated (with Meloxicam) only on a short term bases. Osteoarthritis is a condition which almost everyone will eventually suffer from. Currently 8/10 people aged over 50 suffer, every joint can be effected as the cause of osteoarthritis is the extended use of the joints which causes the cartilage to become thin and uneven. The synovial fluid also becomes thicker and excess is also produced which cause the joint swell, bony spurs can also grow which also lead to further inflammation in the surrounding tissue. All of the conditions mentioned above have one similarity in that they all cause an inflammatory response. Meloxicam inhibits the production of prostaglandins which are the chemical messengers which stimulate an immune response and results in inflammation. It specifically inhibits the cyclo-oxygenase process which is the process in which prostaglandins are produced.

Pharmacological treatments include analgesics, nonsteroidal anti-inflammatory drugs (NSAIDS), opioids hyaluronic acid, corticosteroid injections (Citiation Garcia) or disease-modifying osteoarthritis drugs (DMOADs) such as sodium pentosan polysulfate. Kumagai et al researched the efficacy of subcutaneous injections with sodium pentosan polysulfate on the improvement of cartilage while Garcia-Padilla et al researched the efficacy of intra-articular injections of bicarbonate and calcium gluconate. For treatments to be clinically significant they must alleviate the symptoms; therefore, the treatment should decrease the patient?s level of pain and/or joint stiffness from moderate to mild while resting or being active. The normal range of motion of the knee is 0 to 130 degrees for flexion and 120 to 0 degrees for extension(CITATION Mercks); therefore, within the affected joint the range of motion should increase by 10 degrees. However, the range of motion will be affected by the amount of cartilage lost and scar tissue in the knee joint; therefore, a full recovery in the range of motion should not be

Osteoarthritis is a degenerative joint disease characterized by a fragmentation and erosion of the articular cartilage, which becomes soft, frayed and thinned with alteration of the subchondral bone. It also characterized by the hypertrophy of the bone, changes accompanied by pain and stiffness which finally leads to loss of

Western medicine allow the patient to take pain-relieving drugs during the pain. Treatment for osteoarthritis knee is based on reducing pain and inflammation using anti-inflammatory medications and physical therapy or surgery.

In osteoarthritis, the cartilage at the end of bones wears down and produces rough, hard, edges of bone which cause trouble. This generally begins after 40, and 16 million in the U.S. have it. In rheumatoid arthritis, the cartilage at the end of bones is destroyed and is replaced with scar tissue. Then swelling occurs, and the joints may eventually fuse together. While osteoarthritis only affects individual joints, rheumatoid arthritis ultimately affects all synovial joints in a person's body.

Osteoarthritis (OA) is a chronic degenerative and progressive condition affecting synovial joints, which mainly causes degeneration of hyaline cartilage; Although OA can affect any joint containing hyaline cartilage; Its effects take place most often in the weight bearing joints of lower extremities and the most common large joints involved are knee joints [1].

Rheumatoid arthritis (RA) is an autoimmune disease that affects the cartilage in one 's joints, it is not curable, it can not be stopped, only the pain itself can be lessened. In an average person’s body, the immune system has one job; to attack foreign substances that may enter the body. With the 1.5 million people in the United States that have been diagnosed with rheumatoid arthritis, their bodies are “tricked” or mislead into thinking that the cartilage within their joints is what is foreign. Once their immune system attacks the joints, it causes inflammation within, which then in turn leads to the synovium (lining of the joints) tissue to thicken. The synovium makes a fluid that acts as a lubricant to the joints and helps everything move freely. Once that fluid is gone, swelling and pain is experienced next. After awhile, the cartilage within the joints begins to disintegrate and will eventually cripple the individual. Along with knowing exactly what RA is, by the end of this paper you will know signs and symptoms within the oral cavity and systemically, and you’ll be familiar with how nutrition is related to the progression of this disease.

Osteoarthritis affects around 31 million Americans, irrespective of gender, race and ethnicity. It is estimated that one in two adults in the U.S. develop symptoms of OA in their lifetime. The prevalence of OA is on surge since, the disease is common among the elderly population and their number is estimated to rise to 72 million by 2030 compared to 47.8 million in 2015. In fact, the disease is the highest cause of work loss and cost billions to the U.S. economy (Unites States

oint pain and arthritis is not just experienced in people, but dogs may also get it. Dogs can now be helped with liquid glucosamine for dogs. With a long history of helping people, glucosamine and chondroitin is a logical step towards helping pets. Hopefully with this treatment your dog will up and about with much more comfort than before.