Glucosamine, also known as chitosamine or glucosamine sulfate, is a compound that occurs naturally in the body and is made up of glucose and the amino acid, glutamine. The body needs glucosamine in order to produce glycosaminoglycan, which is a molecule employed in the repair and formation of body tissues, including cartilage. Glucosamine is very effective in alleviating pain caused by osteoarthritis, renewing synovial fluid, repairing joints and rehabilitating cartilage that has been damaged due to the onset of osteoarthritis. Why Glucosamine supplements are necessary Every individual produces a certain amount of glucosamine within their body. This production of glucosamine slows down as a person ages resulting in the hardening of the cartilage …show more content…
How Glucosamine helps in Osteoarthritis Glucosamine supplements are commonly taken to alleviate the symptoms of osteoarthritis, particularly knee arthritis. In osteoarthritis, the cartilage loses its elasticity and stiffens, causing a lot of swelling, pain and loss of movement and making the joint more prone to damage. Glucosamine supplements augment the body's reduced levels of natural glucosamine, which is vital in repairing damaged cartilage and in producing new cartilage. Extensive studies have indicated that glucosamine supplements are highly effective in reducing symptoms of knee osteoarthritis and in retarding its progress. Possible Side Effects Caused by Glucosamine Most studies involving human beings have indicated that usage of glucosamine in the short-term is well-tolerated. Side effects are non-fatal and could include headaches, drowsiness and insomnia. Short term usage of glucosamine could also cause a range of mild and temporary digestive complaints including poor appetite, diarrhea, heartburn, abdominal pain, vomiting and
Glucosamine stimulates production of glycosaminoglycans and proteoglycans, the two essential building blocks of cartilage. Advocates of the treatment say that artificially synthesized glucosamine supplements can jumpstart glucosamine production within joints. Choindroitin is made of many of the same molecules as glucosamine, and essentially serves the same purpose. The long-lasting pain relief and functional improvements that are reported by users of the supplement come as a result of anti-inflammatory agents, an increase in cartilage building activities, and a reduction in the enzymatic destruction of cartilage. Along with a termination in the progression of joint damage, reversal of damage is also highly likely. The rapid pain relief upon initiation of a glucosamine
In only severe case do extreme symptoms present which are very rare. There is no complete cure to any of the condition however using Meloxicam can decrease pain as well as lessen the symptoms. Meloxicam is used to treat both of these conditions for an extended period of time, but osteoarthritis is treated (with Meloxicam) only on a short term bases. Osteoarthritis is a condition which almost everyone will eventually suffer from. Currently 8/10 people aged over 50 suffer, every joint can be effected as the cause of osteoarthritis is the extended use of the joints which causes the cartilage to become thin and uneven. The synovial fluid also becomes thicker and excess is also produced which cause the joint swell, bony spurs can also grow which also lead to further inflammation in the surrounding tissue. All of the conditions mentioned above have one similarity in that they all cause an inflammatory response. Meloxicam inhibits the production of prostaglandins which are the chemical messengers which stimulate an immune response and results in inflammation. It specifically inhibits the cyclo-oxygenase process which is the process in which prostaglandins are produced.
Non-steroidal anti-inflammatory drugs (NSAIDs) are the foundation of medical treatment for osteoarthritis (OA). It is the most common medication taken by an individual experiencing pain due to this degenerative joint disease. Not to mention, NSAIDS are prescribed for pain management in older adults since they are more efficacious than acetaminophen with the absence of central nervous system side effects of opioids
There are very few, if any, side effects to taking glucosamine and chondroitin joint supplements. There is also some evidence that NSAID's can actually INCREASE the progression of arthritis! This is a big risk to take if you are trying to reduce your arthritis symptoms. Glucosamine chondroitin on the other hand can protect the cartilage leading to long term relief from arthritis symptoms.
Osteoarthritis is often associated with degeneration and destruction of articular cartilage. Pathophysiology of the disease is complex which involving of pro-inflammatory cytokines and growth factor that affects the joint homeostasis (McNulty et al, 2013). Recent studies shown increase production of pro-inflammatory cytokines may play a critical role in pathogenesis of osteoarthritis (Bondeson, 2006) which will be discussed in later part.
Osteoarthritis is a degenerative joint disease characterized by a fragmentation and erosion of the articular cartilage, which becomes soft, frayed and thinned with alteration of the subchondral bone. It also characterized by the hypertrophy of the bone, changes accompanied by pain and stiffness which finally leads to loss of
Glucosamine chondroitin is a widely used supplement product for treating canine osteoarthritis without the risks of negative side effects.
Western medicine allow the patient to take pain-relieving drugs during the pain. Treatment for osteoarthritis knee is based on reducing pain and inflammation using anti-inflammatory medications and physical therapy or surgery.
Osteoarthritis (OA) is a chronic degenerative and progressive condition affecting synovial joints, which mainly causes degeneration of hyaline cartilage; Although OA can affect any joint containing hyaline cartilage; Its effects take place most often in the weight bearing joints of lower extremities and the most common large joints involved are knee joints [1].
Osteoarthritis, the most common type of arthritis, is most prevalent in older patients. Osteoarthritis is a degenerative bone disease due to the gradual loss of cartilage. A primary type of osteoarthritis is hip arthritis where it is caused by joint injury, increasing age, and being overweight (“Hip Osteoarthritis,” n.d.). However, osteoarthritis can also be caused by immature joints, inherited defects in cartilage, and extra stress on a patient’s joints (Hip Osteoarthritis,” n.d.). As a result, hip arthritis becomes a huge detriment in patient’s social, emotional, physical lifestyles. In order to treat hip arthritis, doctors choose from a variety of non-drug treatments, medications, and surgeries. Uniquely, I was inspired to research about the treatments of hip arthritis because my very own brother was pronounced with hip arthritis a few years back. Therefore, his determination to battle this disease encouraged me to investigate about the treatment of hip arthritis.
oint pain and arthritis is not just experienced in people, but dogs may also get it. Dogs can now be helped with liquid glucosamine for dogs. With a long history of helping people, glucosamine and chondroitin is a logical step towards helping pets. Hopefully with this treatment your dog will up and about with much more comfort than before.
Osteoarthritis (OA) is the most common form of arthritis. The prevalent population suffering from OA is the elderly, but it may afflict a person of any age, especially upon injury of the joint. This ailment will usually affect loan bearing joints such as the knee or hips, but it can affect any joint. OA is the breakdown of the protective cartilage within the joint, and the patient will suffer from pain, swelling and/or stiffness of the joint, and a decreased range of motion at the joint. These symptoms can have a debilitating effect on a patient by making menial tasks suck as walking, climbing stairs, or even rising out of bed or a chair difficult. Currently, there are various treatment options available for OA but no cure exists; therefore,
Rheumatoid arthritis (RA) is an autoimmune disease that affects the cartilage in one 's joints, it is not curable, it can not be stopped, only the pain itself can be lessened. In an average person’s body, the immune system has one job; to attack foreign substances that may enter the body. With the 1.5 million people in the United States that have been diagnosed with rheumatoid arthritis, their bodies are “tricked” or mislead into thinking that the cartilage within their joints is what is foreign. Once their immune system attacks the joints, it causes inflammation within, which then in turn leads to the synovium (lining of the joints) tissue to thicken. The synovium makes a fluid that acts as a lubricant to the joints and helps everything move freely. Once that fluid is gone, swelling and pain is experienced next. After awhile, the cartilage within the joints begins to disintegrate and will eventually cripple the individual. Along with knowing exactly what RA is, by the end of this paper you will know signs and symptoms within the oral cavity and systemically, and you’ll be familiar with how nutrition is related to the progression of this disease.
Rheumatic or musculoskeletal conditions comprise over 150 diseases and syndromes. One condition called Osteoarthritis (OA) is the most common degenerative joint disease that affects the cartilage. In developed countries it ranks among the top ten for disabling diseases. It is associated with aging and affects the joints that have been continuously stressed throughout the years. This includes the knees, hips, fingers, and lower spine region. The condition presents itself as a loss in flexibility, stiffness, and a deep, achy pain. Treatment of this condition requires a variety of components to fit a person's needs, lifestyle, and health.
Normal rabbits with the age group 20 to 24 month were operated in the Department of Orthopedics, Institute of medical science (Banaras Hindu University) under aseptic conditions. The tissues were washed with phosphate saline buffer. Cartilage tissues were minced into small pieces using tissue homogenizer; small pieces of the tissue were again washed thoroughly with phosphate saline buffer. The enzymes(trypsin and collagenase) were dissolved in Dulbecco’s Modified Eagle’s Medium (DMEM) (Hi Media) supplemented with 50µg/ml gentamycin (Hi Media),10µg/ml Amphotericin (Hi Media) and 50µg/ml of glutamine(Hi Media). Tissue was subjected to sequential enzymatic digestion. The first digestion was done with trypsin in shaking